A Quantitative Investigation of Structure-Function Relationships in a Tendon Fascicle Model

[+] Author and Article Information
K. A. Derwin

University of Michigan, Orthopædic Research Laboratories, G-0161 400 NIB, Ann Arbor, MI 48109-0486

L. J. Soslowsky

University of Pennsylvania, Orthopædic Research Laboratory, 424 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104-6081

J Biomech Eng 121(6), 598-604 (Dec 01, 1999) (7 pages) doi:10.1115/1.2800859 History: Received October 13, 1998; Revised July 28, 1999; Online October 30, 2007


These studies sought to investigate quantitative relationships between the complex composite structure and mechanical properties of tendon. The isolated mouse tail tendon fascicle was chosen as an appropriate model for these so-called “structure-function” investigations. Specifically, collagen fibril diameters and mechanical properties were measured in fascicles from immature (3 week) control, adult (8 week) control, and adult (8 week) Mov13 transgenic mice. Results demonstrated a moderate correlation between mean fibril diameter and fascicle stiffness (r = 0.73, p = 0.001) and maximum load (r = 0.75, p < 0.001), whereas a weak correlation with fascicle modulus (r = 0.39, p = 0.11) and maximum stress (r = 0.48, p = 0.04). An analysis of pooled within-group correlations revealed no strong structure-function trends evidenced at the local or group level, indicating that correlations observed in the general structure-function analyses were due primarily to having three different experimental groups, rather than significant correlations of parameters within the groups.

Copyright © 1999 by The American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In