Remodeling of a Collagenous Tissue at Fixed Lengths

[+] Author and Article Information
J. D. Humphrey

Biomedical Engineering Program, Texas A&M University, College Station, TX 77843-3120

J Biomech Eng 121(6), 591-597 (Dec 01, 1999) (7 pages) doi:10.1115/1.2800858 History: Received September 22, 1998; Revised July 28, 1999; Online October 30, 2007


Mature tissues can often adapt to changes in their chemical, mechanical, or thermal environment. For example, in response to sustained increases or decreases in mechanical loads, some tissues grow and remodel so as to restore the stress or strain to its homeostatic state. Whereas most previous work addresses gross descriptors of tissue growth, this paper introduces a possible cell-mediated mechanism by which remodeling may occur in a soft connective tissue—that the kinetics of collagen deposition and degradation is similar regardless of the configuration of the body at which it occurs. The proposed theoretical framework applies to three-dimensional settings, but it is illustrated by focusing on the remodeling of a uniaxial collagenous tissue that is maintained at a fixed length for an extended period. It is shown that qualitative features expected of such remodeling (e.g., an increased compliance and increased stress-free length when remodeling occurs at an extended length) are easily realized. Growth and remodeling are complex phenomena, however, and are likely accomplished via multiple complementary mechanisms. There is a need, therefore, to identify other candidate mechanisms and, of course, to collect experimental data suitable for testing and refining the possible theories.

Copyright © 1999 by The American Society of Mechanical Engineers
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