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Technical Briefs

Computational Model of the Cerebral Ventricles in Hydrocephalus

[+] Author and Article Information
Shaokoon Cheng1

Prince of Wales Medical Research Institute, University of New South Wales, Sydney 2031, Australias.cheng@powmri.edu.au

Lynne E. Bilston

Prince of Wales Medical Research Institute, University of New South Wales, Sydney 2031, Australia

1

Corresponding author.

J Biomech Eng 132(5), 054501 (Mar 24, 2010) (4 pages) doi:10.1115/1.4001025 History: Received September 18, 2008; Revised May 24, 2009; Posted January 14, 2010; Published March 24, 2010; Online March 24, 2010

Understanding the mechanisms of tissue injury in hydrocephalus is important to shed light on the pathophysiology of this neurostructural disorder. To date, most of the finite element models created to study hydrocephalus have been two-dimensional (2D). This may not be adequate as the geometry of the cerebral ventricles is unique. In this study, a three-dimensional (3D) finite element model of the cerebral ventricles during hydrocephalus is presented. Results from this model show that during hydrocephalus, the periventricular regions experience the highest stress, and stress magnitude is approximately 80 times higher than the cerebral mantle. This suggests that functional deficits observed in hydrocephalic patients could therefore be more related to the damage to periventricular white matter. In addition, the stress field simulated in the tissues based on the 3D model was found to be approximately four times lower than on the 2D model.

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Copyright © 2010 by American Society of Mechanical Engineers
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Figures

Grahic Jump Location
Figure 1

von Mises stress (in MPa) distribution in the 3D brain model

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Figure 2

Biomechanical stresses (in MPa) acting along the periventricular region in hydrocephalus. In order to show the ventricles clearly, a view cut was performed in such a way that part of the exterior surface of the brain was peeled off from the brain model. Directions of the stresses are represented in the sign convention. Positive stresses imply that the tissues are in tension while negative stresses imply that the tissues are in compression.

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Figure 3

FLUVR in the ventricles at the end of the simulation time. Results show that the caudate nucleus (enclosed in eclipse) has low fluid-volume ratio. The highest fluid-volume ratio at the periventricular region (indicated by the arrow) is at a region where the biomechanical stresses in all three directions are high.

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Figure 4

von Mises stress (in MPa) distribution in: (a) 2D plane strain model and (b) an axial plane of the 3D model

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