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Technical Briefs

Design and Development of a Novel Biostretch Apparatus for Tissue Engineering

[+] Author and Article Information
Qiming Pang, Geoffrey M. Siu

Department of Mechanical and Industrial Engineering, University of Toronto, 5 King’s College Road, Toronto, ON, M5S 3G8, Canada

Jean W. Zu1

Department of Mechanical and Industrial Engineering, University of Toronto, 5 King’s College Road, Toronto, ON, M5S 3G8, Canada

Ren-Ke Li

Department of Surgery, University of Toronto, 5 King’s College Road, Toronto, ON, M5S 3G8, Canada

1

Corresponding author.

J Biomech Eng 132(1), 014503 (Dec 08, 2009) (4 pages) doi:10.1115/1.3005154 History: Received September 11, 2007; Revised August 27, 2008; Published December 08, 2009; Online December 08, 2009

A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs noncontact electromagnetic force to uniaxially stretch a rectangular Gelfoam® or RTV silicon scaffold. A reliable controller is implemented to control four stretch parameters independently: extent, frequency, pattern, and duration of the stretch. The noncontact driving force together with the specially designed mount allow researchers to use standard Petri dishes and commercially available CO2 incubators to culture an engineered tissue patch under well-defined mechanical conditions. The culture process is greatly simplified over existing processes. Further, beyond traditional uniaxial stretch apparatuses, which provide stretch by fixing one side of the scaffolds and stretching the other side, the new apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distributions of the strain on the Gelfoam® and GE RTV 6166 silicon scaffolds are quantitatively analyzed.

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Figures

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Figure 1

Schematic of the biostretch apparatus: (1) culture boards; (2) incubator

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Figure 2

Design of the mechanical system: (1) stopper pins, (2) center groove, (3) slot, (4) hole, (5) clamp, (6) electromagnet, (7) culture dish, (8) scaffold, (9) mounting tray, (10) inner stopper pin, and (11) outer stopper pin

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Figure 3

Design of the control system: (a) left: port allocation; (b) right: definition of the stretch plan

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Figure 4

Strain distribution for the middle rows of the Gelfoam and RTV silicone samples

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Figure 5

Strain distribution in the x- and y-axes of a typical sample of Gelfoam

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