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Technical Briefs

Respiratory System Model for Quasistatic Pulmonary Pressure-Volume (P-V) Curve: Generalized P-V Curve Analyses

[+] Author and Article Information
R. Amini, A. Savran, U. Narusawa

Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115

T. A. Barnes

Department of Cardiopulmonary and Exercise Sciences, Northeastern University, Boston, MA 02115

J Biomech Eng 130(4), 044501 (May 16, 2008) (9 pages) doi:10.1115/1.2913345 History: Received May 23, 2007; Revised November 14, 2007; Published May 16, 2008

A normalized P-V curve is proposed for quantitative comparisons of quasistatic P-V curves from different sources, including data from different investigators, airway pressure-volume curves versus transpulmonary pressure-volume curves, normal versus injured respiratory system, and animal tests versus clinical data. Similarities and differences among five different data groups we analyzed are shown to be quantified through the nondimensional pressure range of an individual data set, combined with the magnitudes of two nondimensional parameters of the inflation limb, derived from a respiratory system model previously reported.

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Copyright © 2008 by American Society of Mechanical Engineers
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References

Figures

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Figure 1

(a) P-V curves and (b) P¯-V¯ curves; DG 1 (2)=Data Group 1 (2); P¯, V¯ based on inflation parameters

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Figure 2

(a) Data points and RSM-based P-V curves of DG 4 and (b) RSM-based P¯-V¯ curves of DG 4 with Aft.Injury RSM results shown in filled squares for DG 1 and in X for DG 2; (A) RSM-based P-V curves of DG 5 with data points (filled symbols=data points of peak volume history pressure=40cmH2O, empty symbols=data points of peak volume history pressure=60cmH2O) and (B) RSM-based P¯-V¯ curves of DG 5; both P¯ and V¯ based on inflation parameters

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Figure 3

Vtheory (V from error-function P-V equation) versus V of data: (a) inflation and (b) deflation (DG 3)

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Figure 4

Ptp,theory versus Ptp,data for (a) inflation and (b) deflation (DG 3)

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Figure 5

Ptp versus V (solid) and PawT versus V (dotted) (DG 3)

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Figure 6

Paw (solid) and −Pesoph (dotted) versus Ptp of Data III and VI (for both inflation (top) and deflation (bottom)) (DG 3)

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Figure 7

Inflation P¯-V¯ curves of DG 4: (a) data and (b) error-function P-V equation

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Figure 8

P-V and P¯-V¯ curves in relation to focal-, patchy-, and diffuse-type ARDSs

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