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Technical Briefs

The Association of Wall Mechanics and Morphology: A Case Study of Abdominal Aortic Aneurysm Growth

[+] Author and Article Information
Christopher B. Washington

Allegheny General Hospital,Division of Vascular Surgery, 320 E. North Avenue, South Tower, 14th Floor, Pittsburgh, PA 15212chriswas@andrew.cmu.edu

Judy Shum

 Biomedical Engineering Department, Carnegie Mellon University, 1210 Hamburg Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213jshum@andrew.cmu.edu

Satish C. Muluk

Allegheny General Hospital, Division of Vascular Surgery, 320 E. North Avenue, South Tower, 14th Floor, Pittsburgh, PA 15212smuluk@wpahs.org

Ender A. Finol1

The University of Texas at San Antonio, Department of Biomedical Engineering, AET 1.360, One UTSA Circle, San Antonio, TX 78249ender.finol@utsa.edu

1

Corresponding author.

J Biomech Eng 133(10), 104501 (Nov 03, 2011) (6 pages) doi:10.1115/1.4005176 History: Received June 24, 2011; Accepted September 12, 2011; Revised September 12, 2011; Published November 03, 2011; Online November 03, 2011

The purpose of this study is to evaluate the potential correlation between peak wall stress (PWS) and abdominal aortic aneurysm (AAA) morphology and how it relates to aneurysm rupture potential. Using in-house segmentation and meshing software, six 3-dimensional (3D) AAA models from a single patient followed for 28 months were generated for finite element analysis. For the AAA wall, both isotropic and anisotropic materials were used, while an isotropic material was used for the intraluminal thrombus (ILT). These models were also used to calculate 36 geometric indices characteristic of the aneurysm morphology. Using least squares regression, seven significant geometric features (p < 0.05) were found to characterize the AAA morphology during the surveillance period. By means of nonlinear regression, PWS estimated with the anisotropic material was found to be highly correlated with three of these features: maximum diameter (r = 0.992, p = 0.002), sac volume (r = 0.989, p = 0.003) and diameter to diameter ratio (r = 0.947, p = 0.033). The correlation of wall mechanics with geometry is nonlinear and reveals that PWS does not increase concomitantly with aneurysm diameter. This suggests that a quantitative characterization of AAA morphology may be advantageous in assessing rupture risk.

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Copyright © 2011 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

Time dependency of maximum aneurysm diameter (Dmax ) and peak wall stress (PWS) for the isotropic and anisotropic wall material models during the surveillance period

Grahic Jump Location
Figure 2

Peak wall stress (PWS) relative to the seven significant geometric indices: (a) maximum aneurysm diameter (Dmax ); (b) height (H); (c) length (L); (d) maximum diameter to height ratio (DHr); (e) maximum diameter to proximal neck diameter ratio (DDr); (f) aneurysm sac volume (V); (g) intraluminal thrombus volume (VILT )

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