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Research Papers

Design and Fabrication of a Mechanically Matched Vascular Graft

[+] Author and Article Information
Alexander Rachev, Luc Felden

 GWW School of Mechanical Engineering, GA Institute of Technology, Atlanta, GA 30332

David N. Ku1

 GWW School of Mechanical Engineering, GA Institute of Technology, Atlanta, GA 30332david.ku@me.gatech.edu

1

Corresponding author.

J Biomech Eng 133(9), 091004 (Oct 12, 2011) (8 pages) doi:10.1115/1.4004533 History: Received March 24, 2011; Accepted June 10, 2011; Published October 12, 2011; Online October 12, 2011

The study provides a pathway to design a mechanics-matching vascular graft for an end-to-end anastomosis to a host artery. For functional equivalence, we submit that the graft and a host artery should have equal inner deformed diameters, equal pressure-radius module, and experience equal axial forces when subjected to mean arterial pressure. These criteria for mechanical equivalence are valid for a large class of materials that can be considered as elastic incompressible and orthotropic solids. As an example, specific known artery properties were used to design or select a graft made from a new synthetic biomaterial to demonstrate that reliable and robust technology for graft fabrication is possible.

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Copyright © 2011 by American Society of Mechanical Engineers
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Figures

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Figure 1

Pressure–inner diameter relationship of the host artery (□) and the optimal graft (—)

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Figure 2

Effects of the input parameters on the calculated graft design parameters. The parameters are normalized with respect to the corresponding reference values.

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Figure 3

Schematic of the mold for fabricating the graft prototype. Stainless steel road (1), outer stainless steel cylinder (2), nylon inner screw fitting to center and maintain the road within the cylinder (3).

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Figure 4

Experimental setup. Salubria™ cryogel graft sample (1), scale (2), transparent vessel chamber (3), infusion/withdrawal syringe pump (Harvard Apparatus) (4), reservoir (5), CCD video camera (Philips PCVC740K ToUcam Pro) (6), pressure transducer (Harvard Apparatus) (7), adapter with a pressure dome (8), clamp (9), and computer (10).

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Figure 5

Theoretically predicted (—) and experimentally recorded (×) pressure–normalized diameter relationship for a selected graft as opposed to a custom, optimized graft

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