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Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?

[+] Author and Article Information
Liang Ge

Department of Surgery, University of California, San Francisco, CA; San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121

Fotis Sotiropoulos

Department of Civil Engineering, St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414

J Biomech Eng 132(1), 014505 (Dec 09, 2009) (5 pages) doi:10.1115/1.4000162 History: Received September 17, 2008; Revised June 19, 2009; Posted September 04, 2009; Published December 09, 2009; Online December 09, 2009

Aortic stenosis caused by valve calcification is a major cause of death around the world. Hemodynamic factors have been suggested to be major players in the development of valve calcification, yet a detailed knowledge of the blood flow dynamics as experienced by endothelial cells on valve surfaces is still lacking. In this study we carry out high-resolution numerical simulations of the blood flow through a polymeric trileaflet valve in order to elucidate the differential flow dynamics on the aortic and ventricular sides of the valve leaflets. Limiting streamlines and surface shear stress contours are used to probe and quantify the blood flows on its side. Complicated flow patterns were only observed on the aortic side of the valve near the region where focalized distribution of valve calcification is typically observed.

Copyright © 2010 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

(a) Geometry of the simulated trileaflet valve; (b) incoming flow rate waveform, nondimensionalized by peak flow rate Q0, specified as the inlet flow condition

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Figure 2

2D instantaneous velocity vectors at a center slice (the location of the slice relative to the valve is illustrated as the shaded plane in Fig. 1) parallel to the flow direction. The figures shown in (a)–(c) are corresponding to the three time points t1, t2, and t3 in Fig. 1, respectively.

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Figure 3

Limiting streamlines and surface shear stress (in Pa) contours on the aortic side (left column) and ventricle side (right column); (a)–(c) represent the same time instants as in Fig. 2




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