0
Research Papers

Modeling Material-Degradation-Induced Elastic Property of Tissue Engineering Scaffolds

[+] Author and Article Information
N. K. Bawolin, M. G. Li, W. J. Zhang

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada

X. B. Chen1

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canadaxbc719@mail.usask.ca

1

Corresponding author.

J Biomech Eng 132(11), 111001 (Oct 12, 2010) (7 pages) doi:10.1115/1.4002551 History: Received January 22, 2010; Revised August 14, 2010; Posted September 15, 2010; Published October 12, 2010; Online October 12, 2010

The mechanical properties of tissue engineering scaffolds play a critical role in the success of repairing damaged tissues/organs. Determining the mechanical properties has proven to be a challenging task as these properties are not constant but depend upon time as the scaffold degrades. In this study, the modeling of the time-dependent mechanical properties of a scaffold is performed based on the concept of finite element model updating. This modeling approach contains three steps: (1) development of a finite element model for the effective mechanical properties of the scaffold, (2) parametrizing the finite element model by selecting parameters associated with the scaffold microstructure and/or material properties, which vary with scaffold degradation, and (3) identifying selected parameters as functions of time based on measurements from the tests on the scaffold mechanical properties as they degrade. To validate the developed model, scaffolds were made from the biocompatible polymer polycaprolactone (PCL) mixed with hydroxylapatite (HA) nanoparticles and their mechanical properties were examined in terms of the Young modulus. Based on the bulk degradation exhibited by the PCL/HA scaffold, the molecular weight was selected for model updating. With the identified molecular weight, the finite element model developed was effective for predicting the time-dependent mechanical properties of PCL/HA scaffolds during degradation.

FIGURES IN THIS ARTICLE
<>
Copyright © 2010 by American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.

References

Figures

Grahic Jump Location
Figure 1

Representative volume of a scaffold

Grahic Jump Location
Figure 2

Scaffold sample with a size of 5×5×5 mm3 for mechanical property testing

Grahic Jump Location
Figure 3

Microstructure of a scaffold

Grahic Jump Location
Figure 4

Crystallinity of updating and validation of scaffolds with time

Grahic Jump Location
Figure 5

Longitudinal compressive modulus of scaffolds with time

Grahic Jump Location
Figure 6

Molecular weight estimates for updating scaffolds from FEM model updating

Grahic Jump Location
Figure 7

Experiment and simulation results of the elasticity modulus of HA/PCL scaffolds

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In