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Technical Briefs

Modeling Heat Shock Protein Expression Produced by a Heat Wrap

[+] Author and Article Information
Alfred S. Song

Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712alfred.song@mail.utexas.edu

Kenneth R. Diller

Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712kdiller@mail.utexas.edu

J Biomech Eng 131(7), 074510 (Jun 12, 2009) (4 pages) doi:10.1115/1.3143030 History: Received September 29, 2008; Revised April 24, 2009; Published June 12, 2009

The healing effect of therapeutic hyperthermia induced by widely available heat wrap products is understood to be based on concomitant temperature dependent vasodilation and increase in mass transport. We hypothesize that an additional mechanism of healing associated with increased heat shock protein (HSP) expression is also a contributing factor. HSP expression is controlled by the level and duration of heating and can have a potent effect on healing. We have developed a combined thermal stress and HSP expression model for bioheat transport into the tissues of the back produced by a therapeutic heat wrap. The model predicts temperature distribution in the deep tissues of the back by a modified version of the Pennes (1948, “Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm,” J. Appl. Physiol., 1(2), pp. 93–122) bioheat equation. The model also predicts HSP70/actin concentrations based on existing empirical expression data from our laboratory as a function of heating time and temperature. Thermal boundary conditions were input for a typical heat wrap worn for its functional duration of 8 h or more. Temperatures in the paraspinal muscles of the back increase by a minimum of 1°C after 1 h of heating and persist for at least 2 h. HSP70/actin expression is increased 1.7-fold above the control. The model demonstrates that elevated HSP expression may provide an important contribution to the healing process in injured tissue when a therapeutic heat wrap is worn.

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Copyright © 2009 by American Society of Mechanical Engineers
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Figures

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Figure 5

Prediction of the combined thermal and HSP model

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Figure 1

System geometry: a semi-infinite three layer solid composite of the tissues of the back

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Figure 2

Cubic interpolation of experimental HSP70 expression data in response to a heat stress at 42°C for 1.6 h

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Figure 3

Transient temperatures at selected depths within tissue covered by a heat wrap

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Figure 4

Comparison of model and measured (18) temperatures 20 mm from the surface of the skin for application of a heat wrap

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