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Technical Briefs

Effect of Formalin Fixation on Thermal Conductivity of the Biological Tissue

[+] Author and Article Information
Nachiket M. Kharalkar

Department of Electrical and Computer Engineering, University of Texas at Austin, 1 University Station C0803, Austin, TX 78712nachiket@me.com

Steven C. Bauserman

Department of Pathology, University of Texas Medical Branch, Austin Campus, Brackenridge Hospital, Austin, TX 78701

Jonathan W. Valvano

Department of Electrical and Computer Engineering, University of Texas at Austin, 1 University Station C0803, Austin, TX 78712

J Biomech Eng 131(7), 074508 (Jun 08, 2009) (4 pages) doi:10.1115/1.3147745 History: Received March 20, 2008; Revised April 13, 2009; Published June 08, 2009

Effect of formalin fixation on thermal conductivity of the biological tissues is presented. A self-heated thermistor probe was used to measure the tissue thermal conductivity. The thermal conductivity of porcine aorta, fat, heart, and liver was measured before the formalin fixation and then 1 day, 4 days, and 11 days after formalin fixation. The results indicate that the formalin fixation does not cause a significant change in the tissue thermal conductivity of the tissues studied. In the clinical setting, tissues removed surgically are often fixed in formalin for subsequent pathological analysis. These results suggest that, in terms of thermal properties, it is equally appropriate to perform in vitro studies in either fresh tissue or formalin-fixed tissue.

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Copyright © 2009 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

Thermal conductivity measurements for all the tissue samples

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