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Technology Reviews

Nanoparticles for Thermal Cancer Therapy

[+] Author and Article Information
Emily S. Day, Jennifer G. Morton

Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005

Jennifer L. West

Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005jwest@rice.edu

J Biomech Eng 131(7), 074001 (Jul 16, 2009) (5 pages) doi:10.1115/1.3156800 History: Received November 15, 2008; Revised May 30, 2009; Published July 16, 2009

Advances in nanotechnology are enabling many new diagnostic and therapeutic approaches in cancer. In this review, examples where nanoparticles are employed to induce localized heating within tumors are explored. Approaches to nanoparticle-mediated thermal therapy include absorption of infrared light, radio frequency ablation, and magnetically-induced heating. These approaches have demonstrated high efficacy in animal models, and two are already in human clinical trials.

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Figures

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Figure 1

Varying thicknesses of gold shells upon silica core nanoparticles provide formulations with tunable optical properties. Near-infrared absorbing particles can be easily fabricated.

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Figure 2

Magnetic resonance thermal imaging was used to measure temperature profiles in nanoshell-treated tumors during NIR illumination. Both tumor sites underwent rapid heating, while the normal tissue in between did not experience a significant change in temperature.

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Figure 3

Temperature inside the prostate and magnetic field strength plotted versus time during the course of magnetic fluid hyperthermia. The thermocouple was moved through the tumor to find the position with maximum temperature, where it was left for the remainder of the session. The downward spike in temperature indicates the border of the prostate. Temperature increased until the magnetic field was removed, at which point the temperature dropped rapidly ((32), with permission from Taylor & Francis Group, http://www.informaworld.com).

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Figure 4

Left image: preoperative magnetic resonance image displays the location of the tumor in the right posterior horn of the ventricle; right image: postoperative CT verifies magnetic nanoparticle accumulation in the tumor ((39), Fig. 1, with permission from Springer Science+Business Media).

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Figure 5

H and E staining reveals a greater presence of tissue necrosis in tumors receiving GNPs before rf field exposure than those receiving water only ((42), with permission from Elsevier).

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