Technical Briefs

Modeling of Laser Coagulation of Tissue With MRI Temperature Monitoring

[+] Author and Article Information
Xin Chen1

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106

Gerald M. Saidel

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106


Corresponding author. Also at the Department of Radiation Oncology, University of Arkansas for Medical Science, 4301 West Markham Street #771, Little Rock, AR 72205.

J Biomech Eng 132(6), 064503 (Apr 28, 2010) (4 pages) doi:10.1115/1.4001395 History: Received June 29, 2009; Revised March 03, 2010; Posted March 11, 2010; Published April 28, 2010; Online April 28, 2010

Light energy from a laser source that is delivered into body tissue via a fiber-optic probe with minimal invasiveness has been used to ablate solid tumors. This thermal coagulation process can be guided and monitored accurately by continuous magnetic resonance imaging (MRI) since the laser energy delivery system does not interfere with MRI. This report deals with mathematical modeling and analysis of laser coagulation of tissue. This model is intended for “real-time” analysis of magnetic resonance images obtained during the coagulation process to guide clinical treatment. A mathematical model is developed to simulate the thermal response of tissue to a laser light heating source. For fast simulation, an approximate solution of the thermal model is used to predict the dynamics of temperature distribution and tissue damage induced by a laser energy line source. The validity of these simulations is tested by comparison with MRI-based temperature data acquired from in vivo experiments in rabbits. The model-simulated temperature distribution and predicted lesion dynamics correspond closely with MRI-based data. These results demonstrate the potential for using this combination of fast modeling and MRI technologies during laser heating of tissue for online prediction of tumor lesion size during laser heating.

Copyright © 2010 by American Society of Mechanical Engineers
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Figure 1

Symbolic diagram: 3D model of a finite-line laser source in a cube of tissue. The light diffusion tip of the laser probe is along the z-axis in the center of the x-y plane.

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Figure 2

Contour plots of the model-simulated temperature T(z,x,tj) at t1=30 s and 540 s in a plane with the laser probe along the z-axis and y=0. The bold line is the laser tip.

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Figure 3

Tissue temperature distributions after laser heating of (a) 160 s, (b) 340 s, and (c) 540 s at the plane, crossing the laser fiber tip at z=0 mm and 3 mm. Model-simulated temperature TM and average MRI temperature TG is represented by solid lines and circles, respectively.

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Figure 4

Comparison of the lesion area dynamics: model-simulated lesion area AM (solid line) from probability of cell damage from heating; estimated lesion area AG (solid dots) from MRI temperature threshold



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