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Research Papers

Thin Film Nitinol Microstent for Aneurysm Occlusion

[+] Author and Article Information
Youngjae Chun

Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 32-135 Engineering IV, Los Angeles, CA 90095yjchun@ucla.edu

Daniel S. Levi

Pediatric Cardiology, Mattel Children’s Hospital UCLA, B2-427, 10833 Le Conte Avenue, Los Angeles, CA 90095-1743dlevi@ucla.edu

K. P. Mohanchandra

Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 32-135 Engineering IV, Los Angeles, CA 90095kpmohan@seas.ucla.edu

Fernando Vinuela

Radiological Sciences, David Geffen School of Medicine, UCLA, BL-428 CHS, Los Angeles, CA 90095-1721fvinuela@mednet.ucla.edu

Gregory P. Carman

Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 38-137M Engineering IV, Los Angeles, CA 90095carman@seas.ucla.edu

J Biomech Eng 131(5), 051014 (Apr 17, 2009) (8 pages) doi:10.1115/1.3118769 History: Received July 17, 2008; Revised February 11, 2009; Published April 17, 2009

Thin film nitinol produced by sputter deposition was used in the design of microstents intended to treat small vessel aneurysms. Thin film microstents were fabricated by “hot-target” dc sputter deposition. Both stress-strain curves and differential scanning calorimetry curves were generated for the film used to fabricate stents. The films used for stents had an Af temperature of approximately 36°C allowing for body activated response from a microcatheter. The 10μm film was only slightly radio-opaque; thus, a Td marker was attached to the stents to guide fluoroscopic delivery. Thin film microstents were tested in a flow loop with and without nitinol support skeletons to give additional radial support. Stents could be compressed into and easily delivered with <3 Fr catheters. Theoretical frictional and wall drag forces on a thin film nitinol small vessel vascular stent were calculated, and the radial force exerted by thin film stents was evaluated theoretically and experimentally. In vivo studies in swine confirmed that thin film nitinol microstents could be deployed accurately and consistently in the swine cranial vasculature.

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Copyright © 2009 by American Society of Mechanical Engineers
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Figures

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Figure 4

Stress versus strain behavior of superelastic thin film nitinol

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Figure 9

Deployment of single-zigzag wire-reinforced structure with thin film nitinol stent in the right femoral artery

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Figure 3

DSC plot of superelastic thin film nitinol for microstent construction

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Figure 2

Three different types of nitinol wire-based reinforcements: (a) coil, (b) single-zigzag design, (c) dual-zigzag design, and (d)–(f) deployed fashion, respectively

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Figure 1

(a) Schematic diagram of a thin film nitinol microstent for treatment of small vessel aneurysms and (b) force balance of thin film nitinol stent and blood flow

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(a) Surface topology and (b) contact angle results of thin film nitinol microstent

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Figure 6

Thickness versus radial force of thin film nitinol and wire-reinforced structures

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Figure 7

Pulsatile flow velocity versus migration starting velocities of thin film stents

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Figure 8

(a) Radiograph of implanted thin film nitinol microstent for visibility and (b) internal profile of swine’s brain artery

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