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TECHNICAL PAPERS: Fluids/Heat/Transport

Numerical Modeling of In Vivo Plate Electroporation Thermal Dose Assessment

[+] Author and Article Information
S. M. Becker

Mechanical and Aerospace Engineering, North Carolina State University, Box 7910, Raleigh, NC 27695smbecker@unity.ncsu.edu

A. V. Kuznetsov

Mechanical and Aerospace Engineering, North Carolina State University, Box 7910, Raleigh, NC 27695

J Biomech Eng 128(1), 76-84 (Aug 18, 2005) (9 pages) doi:10.1115/1.2132375 History: Received April 04, 2005; Revised August 18, 2005

Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell membrane, which normally acts as a barrier to large molecule transport into the cell interior, is temporarily destabilized due to the development of pores in the cell membrane. Consequently, agents that are ordinarily unable enter the cell are able to pass through the cell membrane. Of possible concern when exposing biological tissue to an electric field is thermal tissue damage associated with joule heating. This paper explores the thermal effects of various geometric, biological, and electroporation pulse parameters including the blood vessel presence and size, plate electrode configuration, and pulse duration and frequency. A three-dimensional transient finite volume model of in vivo parallel plate electroporation of liver tissue is used to develop a better understanding of the underlying relationships between the physical parameters involved with tissue electroporation and resulting thermal damage potential.

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Copyright © 2006 by American Society of Mechanical Engineers
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Figures

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Figure 2

x-y plane temperature profiles: varying axial positions at t=15s

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Figure 3

Transient temperature profiles at y=0 (vessel centerline); t is time after last pulse cycle

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Figure 4

EM43 at t=90s: Effect of blood vessel radius

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Figure 5

EM43 at t=90s (after last pulse cycle): Small vessel effect

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Figure 6

EM43 at t=90s (after last pulse cycle): Effect of electrode plate spacing

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Figure 7

EM43 at t=90s (after last pulse cycle): Effect of pulse duration—number of pulses administered

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Figure 8

Temperature at t=0s (after last pulse cycle): Effect of pulse duration—number of pulses administered

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Figure 9

EM43 at t=90s (after last pulse cycle): Effect of pulse frequency

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Figure 10

Temperature at t=0s (after last pulse cycle): Effect of pulse frequency

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