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TECHNICAL PAPERS: Cell

What are the Relevant Parameters for the Geometrical Optimization of an Implantable Bioartificial Pancreas?

[+] Author and Article Information
Jean-Luc Dulong

 Technological University of Compiègne, UMR 6600 CNRS, Department of Biological Engineering, Compiègne, France

Cécile Legallais1

 Technological University of Compiègne, UMR 6600 CNRS, Department of Biological Engineering, Compiègne, Francececile.legallais@utc.fr

1

Corresponding author.

J Biomech Eng 127(7), 1054-1061 (Jul 18, 2005) (8 pages) doi:10.1115/1.2073407 History: Received December 19, 2003; Revised July 18, 2005

A sphere within a cylinder representing the islet encapsulated in a hollow fiber can model an implantable bioartificial pancreas. Based on a finite element model for insulin response to a glucose load in the presence of various oxygen supplies, the present study aimed at pointing out the major parameters influencing this secretion. The computational results treated with the Taguchi method clearly demonstrated that geometrical parameters (fiber length and islet density) should be precisely optimized for an enhanced insulin response. This requires the collection of more relevant experimental data concerning the islet oxygen consumption. Moreover, the relative errors on glucose consumption or insulin secretion by the islets do not seem to affect the whole optimization process, which should focus on the oxygen supply to islets.

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Copyright © 2005 by American Society of Mechanical Engineers
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Figures

Grahic Jump Location
Figure 1

Geometric sketch of the model; a sphere representing the islet is located at the center of a cylinder. Mass transfer of the three studied solutes are indicated: glucose and oxygen come from the outside to the sphere, insulin is secreted by the islet and is transferred to the outside.

Grahic Jump Location
Figure 2

Insulin secretion from an isolated islet, nonencapsulated (black curve) or from an encapsulated islet (gray curve). The mass of insulin released was calculated between t0 and t0+20min, and represented by the areas under the curves: mass secreted by an isolated islet (black portion) or by an encapsulated islet (gray portion).

Grahic Jump Location
Figure 3

Absolute values of the parameters or interactions effects, calculated with the first experimental design. Bars were classed by decreasing value.

Grahic Jump Location
Figure 4

Absolute values of the parameters or interactions effects, calculated with the second experimental design. Bars were classed by decreasing value.

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