TECHNICAL PAPERS: Fluids/Heat/Transport

A Mechanistic Model for Quasistatic Pulmonary Pressure-Volume Curves for Inflation

[+] Author and Article Information
R. Amini, K. Creeden, U. Narusawa

Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115

J Biomech Eng 127(4), 619-629 (Feb 22, 2005) (11 pages) doi:10.1115/1.1934079 History: Received April 21, 2004; Revised February 22, 2005

A mechanistic model of the respiratory system is proposed to understand differences in quasistatic pressure-volume (p-V) curves of the inflation process in terms of the alveolar recruitment and the elastic distension of the wall tissues. In the model, a total respiratory system consists of a large number of elements, each of which is a subsystem of a cylindrical chamber fitted with a piston attached to a spring. The alveolar recruitment is simulated by allowing a distribution of the critical pressure at which an element opens; while the wall distension is represented by the piston displacement. Relations are derived between parameters in the error-function p-V model equation and properties of the mechanistic model. The parameters of the model-based p-V equation are determined for clinical data sets of patients with acute respiratory distress syndrome.

Copyright © 2005 by American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.



Grahic Jump Location
Figure 1

(a) A typical quasistatic pulmonary pressure-volume curve, (b) V(p) vs Vp(p)

Grahic Jump Location
Figure 2

Error-function p-V equation and inflation data points

Grahic Jump Location
Figure 3

A schematic diagram of mechanistic model of TRS element

Grahic Jump Location
Figure 4

V (volume predicted by model-based p-V equation) vs V (volume of data) for a specified pressure

Grahic Jump Location
Figure 5

Model-based p-V equation, Eq. 13, vs data points for inflation process. Solid: solution for low-pressure region; dotted: solution for high-pressure region.

Grahic Jump Location
Figure 6

Data points for inflation (unfilled) and deflation (filled). p-V equation of mechanistic model for inflation (I) and the error function p-V equation for deflation (D).

Grahic Jump Location
Figure 7

VUd (predicted from the mechanistic model) vs VUd (of error-function p-V equation for deflation)




Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In