Nucleus Implant Parameters Significantly Change the Compressive Stiffness of the Human Lumbar Intervertebral Disc

[+] Author and Article Information
Abhijeet Joshi

Department of Materials Science and Engineering, Drexel University, Philadelphia PA 19104

Samir Mehta

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia PA 19104

Edward Vresilovic

Department of Biomedical Engineering, Drexel University, Philadelphia PA 19104

Andrew Karduna

Department of Human Physiology, University of Oregon, Eugene OR 97403

Michele Marcolongo1

Department of Materials Science and Engineering, Drexel University, Philadelphia PA 19104marcolms@drexel.edu


Corresponding author.

J Biomech Eng 127(3), 536-540 (Jan 31, 2005) (5 pages) doi:10.1115/1.1894369 History: Received September 27, 2003; Revised November 27, 2004; Accepted January 31, 2005

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

Copyright © 2005 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 2

Effect of nucleus implant parameter variations on the compressive stiffness of the lumbar intervertebral disc

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Figure 3

Stiffness versus implant volume ratio of nucleus implant at different strain levels

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Figure 1

Schematic of implantation method of a human lumbar intervertebral disc




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