Because thoroughbred racehorses have a high incidence of forelimb musculoskeletal injuries, a model was desired to screen potential risk factors for injuries. This paper describes the development of a musculoskeletal model of the thoroughbred forelimb and a dynamic simulation of the motion of the distal segments during the stance phase of high-speed gallop. The musculoskeletal model is comprised of segment, joint, muscle-tendon, and ligament information. The dynamic simulation incorporates a proximal forward-driving force, a distal ground reaction force model, muscle activations, and initial positions and velocities. A simulation of the gallop after transection of an accessory ligament demonstrated increased soft tissue strains in the remaining support structures of the distal forelimb. These data were consistent with those previously reported from in vitro experimental data and supported usefulness of the model for the study of distal forelimb soft tissue mechanics during the stance phase of the gallop.