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TECHNICAL PAPERS: Soft Tissue

Anisotropic Mechanical Properties of Tissue Components in Human Atherosclerotic Plaques

[+] Author and Article Information
Gerhard A. Holzapfel, Gerhard Sommer

  Graz University of Technology, Institute for Structural Analysis, Computational Biomechanics, Schiesstattgasse 14-B, 8010 Graz, Austria

Peter Regitnig

Medical University Graz, Institute of Pathology, Auenbruggerplatz 25, 8036 Graz, Austria

J Biomech Eng 126(5), 657-665 (Nov 23, 2004) (9 pages) doi:10.1115/1.1800557 History: Received February 16, 2004; Revised April 16, 2004; Online November 23, 2004
Copyright © 2004 by ASME
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References

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Figures

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Human external iliac artery, specimen I: (a) segmented macroscopic view, (b) segmented histological section (EVG coloring)—transmitted light microscopic photograph, (c) high resolution magnetic resonance image of the same artery, filtered and (manually) segmented. The histological section and the magnetic resonance image are taken from the same location.
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Macroscopic view of eight human stenotic iliac arteries, specimens II–IX. Top ruler scale: one side of a square characterizes 1 mm.
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Representative axial and circumferential strips excised from a dissected adventitial layer.
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Eleven strip samples prepared for mechanical testing (from specimen V). Samples of the tissue types A, M-nos, I-nos, I-fc, and I-fm in both directions, and one sample of the calcification I-c in the circumferential direction.
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Representative photograph of a fractured tissue component (specimen I), nondiseased intima I-nos tested in the circumferential direction.
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Uniaxial tensile stress–stretch responses of different human tissues in the circumferential and axial directions. (a), (b) are stress–stretch plots for the adventitia A, (c), (d) are plots for the healthy and diseased media (M-nos and M-f), and (e), (f) are related to the healthy intima I-nos. Labels I-f, VII-f, and VIII-f in (c), (d), indicate fibrotic media samples from specimens I, VII, and VIII, respectively.
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Uniaxial tensile stress–stretch responses of different human tissues in the circumferential and axial directions. (a), (b) are stress–stretch plots for the fibrous cap I-fc, while (c), (d) are plots for the fibrotic intima samples at the medial border I-fm.

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