Measurement of Strain in Physical Models of Brain Injury: A Method Based on HARP Analysis of Tagged Magnetic Resonance Images (MRI)

[+] Author and Article Information
P. V. Bayly, S. Ji, S. K. Song, R. J. Okamoto, P. Massouros, G. M. Genin

Mechanical and Aerospace Engineering ChemistryBiomedical Engineering

J Biomech Eng 126(4), 523-528 (Sep 27, 2004) (6 pages) doi:10.1115/1.1785811 History: Received November 20, 2003; Revised January 26, 2004; Online September 27, 2004
Copyright © 2004 by ASME
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Simulated images of a grid of “tag lines” (a) undeformed and (b) subjected to simple shear. Synthetic tag lines, obtained from isocontours of harmonic phase (HARP), are superimposed. (c–e) Horizontal, vertical and shear strain fields for this example.
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(a) A sample tagged MR image of the rotationally accelerated gel phantom. (b) The same image with synthetic tag lines formed from HARP isocontours. (d–f) Radial, circumferential and shear strain components estimated using the gradient-based approach.
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(a) Undeformed tagged image of the brain of a rat pup (P8). (b) Deformed tagged image of the rat brain during indentation of the skull by a force of approximately 1 N. (c–d) Train of force pulses measured using this impact sequence outside the scanner, with a different animal. (Note: amplifier was AC-coupled, causing an initial transient and a non-zero baseline in Fig. 3c.)
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(a–c) Horizontal, vertical and shear strain components estimated for the P8 rat pup. (d–f) Horizontal, vertical and shear strain components of strain from a FE model of the static compression of an isotropic, homogeneous, linearly elastic 2D brain (qualitative comparison only).




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