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TECHNICAL PAPERS: Soft Tissue

Strain-Rate Sensitive Mechanical Properties of Tendon Fascicles From Mice With Genetically Engineered Alterations in Collagen and Decorin

[+] Author and Article Information
Paul S. Robinson, Tony W. Lin, Paul R. Reynolds, Louis J. Soslowsky

McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA

Kathleen A. Derwin

Department of Biomedical Engineering and the Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

J Biomech Eng 126(2), 252-257 (May 04, 2004) (6 pages) doi:10.1115/1.1695570 History: Received November 08, 2002; Revised August 03, 2003; Online May 04, 2004
Copyright © 2004 by ASME
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References

Figures

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Fascicle prepared and mounted in test fixture. Bar=2 mm
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Typical data and calculations for a slow (0.5%/s) test. Stress vs. optical strain data was fit with a nth order polynomial (4<n<9). Modulus was calculated as the slope of the polynomial at its inflection point (diamond).
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Slow (0.5%/s) constant strain rate test mechanical properties. A: Maximum Load, B: Stiffness, C: Maximum Stress, D: Modulus. Bars are mean+standard deviation. CTL8=adult normal, C1TJ8=collagen accumulation, C1M8=collagen reduction, DKO8=decorin knockout, CTL3=immature normal. *=significantly different from CTL8 (p<0.003).
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Fast (50%/s) constant strain rate test mechanical properties. A: Maximum Load, B: Stiffness, C: Maximum Stress, D: Modulus. Bars are mean+standard deviation. CTL8=adult normal, C1TJ8=collagen accumulation, C1M8=collagen reduction, DKO8=decorin knockout, CTL3=immature normal. *=significantly different from CTL8 (p<0.05).
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Fast ramp/Slow ramp ratios of mechanical properties of each mouse group. A fast/slow ratio of 1.0 (thick horizontal bar) indicates no strain rate sensitivity. Bars are mean±standard deviation. CTL8=adult normal, C1TJ8=collagen accumulation, C1M8=collagen reduction, DKO8=decorin knockout, CTL3=immature normal. *=property strain rate sensitive (fast/slow ratio>1.0,p<0.05)#=significant difference from CTL8 (p<0.05).

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