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TECHNICAL PAPERS

An Integrated Finite-Element Approach to Mechanics, Transport and Biosynthesis in Tissue Engineering

[+] Author and Article Information
Bram G. Sengers, Cees W. J. Oomens, Frank P. T. Baaijens

Eindhoven University of Technology, Department of Biomedical Engineering, P.O. Box 513, 5600 MB Eindhoven, The Netherlands

J Biomech Eng 126(1), 82-91 (Mar 09, 2004) (10 pages) doi:10.1115/1.1645526 History: Received August 01, 2002; Revised August 20, 2003; Online March 09, 2004
Copyright © 2004 by ASME
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Figures

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Schematic representation of the modeling approach, showing the coupling between the different model components and the model inputs. Outputs are defined as the concentration of functional tissue components. Dashed routes will not be considered in the current study.
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(a) Unconfined compression setup. (b) Finite element mesh containing 24 elements.
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Maximum local fluid velocity induced by dynamic loading in the last cycle before t=4000 s, plotted in the undeformed geometry.
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Desorption of an initially homogeneous concentration for different loading conditions and dispersion parameters. (a), (b): Dd=0 mm. (c), (d): Dd=0.01 mm. (e), (f): Dd=0.1 mm. Left: Matrix component concentration profiles after 4000 s. Right: Evolution of total matrix component content in time.
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(a) Steady state concentration profile resulting from diffusion and uptake for both the small and large solute. (b) Large solute concentration profiles at t=87000 for different loading frequencies and dispersion parameters.
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Matrix component profiles at t=87000 for different loading frequencies and dispersion parameters. (a) Synthesis independent of transport. (b) Synthesis limited by a small solute. (c) Synthesis limited by a large solute.
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Integrated effect of different loading frequencies and dispersion parameters on total biosynthesis at t=87000. The white bar represents the total synthesis. The black bar represents the fraction retained in the construct. (a) Synthesis independent of transport. (b) Synthesis limited by a small solute. (c) Synthesis limited by a large solute.

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