An In Vivo Method for Measuring Turbulence in Mechanical Prosthesis Leakage Jets

[+] Author and Article Information
Brandon R. Travis

Thomas D. Christensen, Morten Smerup, Morten S. Olsen, J. Michael Hasenkam

Department of Cardiothoracic and Vascular Surgery, Århus University Hospital, Skejby Sygehus, Århus, Denmark Institute for Experimental Clinical Research, Århus University Hospital, Skejby Sygehus, Århus, Denmark

Hans Nygaard

Department of Cardiothoracic and Vascular Surgery, Århus University Hospital, Skejby Sygehus, Århus, Denmark The Engineering College of Århus, Århus, Denmark

J Biomech Eng 126(1), 26-35 (Mar 09, 2004) (10 pages) doi:10.1115/1.1644563 History: Received September 05, 2002; Revised October 01, 2003; Online March 09, 2004
Copyright © 2004 by ASME
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Hasenkam,  J. M. , 1996, “Hemodynamic evaluation of a new bileaflet valve prosthesis: an acute animal experimental study,” J. Heart Valve Dis., 5(6), pp. 574–580.
Yoganathan, A. P., personal communication.
Gross,  J. M. , 1996, “A microstructural flow analysis within a bileaflet mechanical heart valve hinge,” J. Heart Valve Dis., 5(6), pp. 581–590.
Ellis,  J. T. , 1996, “Velocity measurements and flow patterns within the hinge region of a Medtronic Parallel bileaflet mechanical valve with clear housing,” J. Heart Valve Dis., 5(6), pp. 591–599.
Woo,  Y. R., and Yoganathan,  A. P., 1986, “In vitro pulsatile flow velocity and shear stress measurements in the vicinity of mechanical mitral heart valve prostheses,” J. Biomech., 19(1), pp. 39–51.
Baldwin,  J. T. , 1991, “Mean velocities and Reynolds stresses within regurgitant jets produced by tilting disc valves,” ASAIO Trans., 37(3), pp. M348–M349.
Ellis,  J. T. , 1996, “An in vitro investigation of the retrograde flow fields of two bileaflet mechanical heart valves,” J. Heart Valve Dis., 5(6), pp. 600–606.
Maymir,  J. C. , 1997, “Effects of tilting disk heart valve gap width on regurgitant flow through an artificial heart mitral valve,” Artif. Organs, 21(9), pp. 1014–1025.
Steegers,  A. , 1999, “Leakage flow at mechanical heart valve prostheses: improved washout or increased blood damage?,” J. Heart Valve Dis., 8(3), pp. 312–323.
Ellis,  J. T., and Yoganathan,  A. P., 2000, “A comparison of the hinge and near-hinge flow fields of the St Jude medical hemodynamic plus and regent bileaflet mechanical heart valves,” J. Thorac. Cardiovasc. Surg., 119(1), pp. 83–93.
Travis,  B. R. , 2002, “An analysis of turbulent shear stresses in leakage flow through a bileaflet mechanical prostheses,” J. Biomech. Eng., 124(2), pp. 155–165.
Meyer,  R. S. , 2001, “Laser Doppler velocimetry and flow visualization studies in the regurgitant leakage flow region of three mechanical mitral valves,” Artif. Organs, 25(4), pp. 292–299.
Lamson,  T. C. , 1993, “Relative blood damage in the three phases of a prosthetic heart valve flow cycle,” ASAIO Trans., 39(3), pp. M626–M633.
Travis,  B. R. , 2001, “Bileaflet aortic valve prosthesis pivot geometry influences platelet secretion and anionic phospholipid exposure,” Ann. Biomed. Eng., 29(8), pp. 657–664.
Travis,  B. R. , 2001, “The sensitivity of indicators of thrombosis initiation to a bileaflet prosthesis leakage stimulus,” J. Heart Valve Dis., 10(2), pp. 228–238.
Cockelet G., “The rheology of human blood” Fung Y.
Pohl,  M. , 1996, “In vitro testing of artificial heart valves: comparison between Newtonian and non-Newtonian fluids,” Artif. Organs, 20(1), pp. 37–46.
Nygaard,  H. , 1994, “A new perivascular multi-element pulsed Doppler ultrasound system for in vivo studies of velocity fields and turbulent stresses in large vessels,” Med. Biol. Eng. Comput., 32(1), pp. 55–62.
Nygaard,  H. , 1994, “Turbulent stresses downstream of three mechanical aortic valve prostheses in human beings,” J. Thorac. Cardiovasc. Surg., 107(2), pp. 438–446.
Garbani,  J. L., Forster,  F. K., and Jorgensen,  J. E., 1982, “Measurement of fluid turbulence based on pulsed ultrasound techniques,” J. Fluid Mech., 118, pp. 445–470.
Lieber,  B. B. , 1989, “On the discrimination between band-limited coherent and random apparent stresses in transitional pulsatile flow,” J. Biomech. Eng., 111(1), pp. 42–46.
Benedict,  L. H., and Gould,  R. D., 1996, “Towards better uncertainty estimates for turbulent statistics,” Exp. Fluids, 22, pp. 129–136.
Tennekes, H., and Lumley, J. L. 1972, A first course in turbulence MIT Press, Cambridge, Mass.
Grigioni,  M. , 2000, “On the monodimensional approach to the estimation of the highest reynolds shear stress in a turbulent flow,” J. Biomech., 33(6), pp. 701–708.
Flachskampf,  F. A. , 1991, “Patterns of normal transvalvular regurgitation in mechanical valve prostheses,” J. Am. Coll. Cardiol., 18(6), pp. 1493–1498.
Yoganathan,  A. P. , “Oblique flow vectors from dispersing jets produce the velocity overestimation on angle corrected continuous wave Doppler studies: in vitro laser Doppler investigations,” Circulation, 76(Supp IV), pp. 355.
Blevins, R. D. 1984, Applied fluid dynamics handbook Van Nostrand Reinhold Co., New York, N.Y.
Sahn,  D. J., 1988, “Instrumentation and physical factors related to visualization of stenotic and regurgitant jets by Doppler color flow mapping,” J. Am. Coll. Cardiol., 12(5), pp. 1354–1365.
Stewart,  S. F., Burte,  F., and Clark,  R. E., 1993, “Quantification of asymmetric valvular regurgitant jets by color Doppler ultrasound in vitro,” Echocardiography, 10(1), pp. 23–36.


Grahic Jump Location
Leakage jet locations within interrogation area, and with respect to the valve. Turbulent normal stresses during leakage flow, calculated from maximum velocity measurements, cyclic averaging, and 20 ms phase windows, are defined for each jet found. Dots on the 2-D plot above the valve show location within the interrogation area at which data were acquired.
Grahic Jump Location
Power spectrum of the measurements obtained from a specific location in jet 1
Grahic Jump Location
Phase delay introduced by high pass filtering. (a) and (b) were created from data which were cyclic averaged, while (c) and (d) were created from data which were high pass filtered. The phase windows over which analyses were completed are shown in the left ventricular pressure curves above (a) and (b).
Grahic Jump Location
Left atrial pressure, left ventricular pressure, and velocity over systole. The rise in left atrial pressure corresponds with a decrease in velocity.
Grahic Jump Location
Traverse apparatus used to move ultrasound transducer. The mounting portion of the apparatus is sewn to the valve, allowing a precise positioning of an ultrasound transducer with respect to the valve.
Grahic Jump Location
Interrogation area of study with respect to the valve and ultrasound transducer. The Cartesian axes used in this study are defined here.
Grahic Jump Location
Velocity profiles obtained from (a) mean velocity measurements and (b) maximum velocity measurements during the axisymmetric, laminar free jet experiment
Grahic Jump Location
Flow chart demonstrating data analysis method
Grahic Jump Location
A bileaflet mechanical prosthesis, emphasizing the pivot region.



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