Particle Deposition in Arteries Ex Vivo: Effects of Pressure, Flow, and Waveform

[+] Author and Article Information
Naomi C. Chesler

Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405-0156

Omyekachi C. Enyinna

Biomedical Engineering Program, University of Vermont, Burlington, VT 05405-0156

J Biomech Eng 125(3), 389-394 (Jun 10, 2003) (6 pages) doi:10.1115/1.1572905 History: Received July 23, 2001; Revised February 03, 2003; Online June 10, 2003
Copyright © 2003 by ASME
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Grahic Jump Location
Representative flowrate (A) and pressure (B) generated during steady and pulsatile perfusion of a porcine carotid artery ex vivo at a mean pressure of 100 mm Hg.
Grahic Jump Location
Confocal laser microscopy images of vessels perfused with microspheres under steady (A, B) and pulsatile (C, D) conditions. Images A and C are control (no-flow), B and D are experimental (flow). Probes fluoresce in the red wavelength; cell nuclei fluoresce green. Images were taken at 10× magnification.
Grahic Jump Location
Sphere area to intimal surface area ratio quantified from conofocal laser microscopy images of vessels perfused under steady (white), pulsatile (light gray) and oscillatory (dark gray) waveforms at mean pressures of 100 mmHg and 200 mmHg. Hatching differentiates flow (unhatched) from no flow (hatched). Bars represent mean±standard deviation.
Grahic Jump Location
Baseline-adjusted sphere deposition data for steady, pulsatile and oscillatory waveforms to determine the additive effect of flow. Mean values for each group are shown.
Grahic Jump Location
Scanning electron micrograph showing microspheres clustered and deposited along the intima.
Grahic Jump Location
Ex vivo perfusion system for pulsatile waveform, variable pressure.




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