Morphology and Stress-Strain Properties Along the Small Intestine in the Rat

[+] Author and Article Information
Yanling Dou

Institute of Experimental Clinical Research, Aarhus University, Denmark Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, P.R. China

Jingbo Zhao

Institute of Experimental Clinical Research, Aarhus University, Denmark

Hans Gregersen

Institute of Experimental Clinical Research, Aarhus University, Denmark Biomechanics Lab, Center for Sensory-Motor Interaction, Aalborg University and Department of Surgery A, Aalborg Hospital, Denmark

J Biomech Eng 125(2), 266-273 (Apr 09, 2003) (8 pages) doi:10.1115/1.1560140 History: Received October 01, 1999; Revised October 01, 2002; Online April 09, 2003
Copyright © 2003 by ASME
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Grahic Jump Location
Schematic drawings of intestinal segment in the pressurized state (top), the no-load state (left bottom) and the zero-stress state (right bottom). C, h, and r denote the circumferential length, the wall thickness, and the radius. The wall thickness was measured at three locations in each specimen and averaged. α is the opening angle at zero-stress state that was defined as the angle subtended by two radii drawn from the midpoint of the wall to the inner tips of the two ends of the specimen. The subscripts i, o, n, z and p refer to the inner (mucosal) surface, outer (serosal) surface, the no-load state, the zero-stress state and the pressurized state.
Grahic Jump Location
Photographs showing specimens of the duodenum (top), the jejunum (middle) and the ileum (bottom) in the no-load state (left, closed rings) and the zero-stress state (right, opened pieces by a radial cut on antimesenteric side). The duodenal ring turned inside out when cut open.
Grahic Jump Location
Intestinal mass per centimeter length in the duodenum (D), jejunum (J), and ileum (I). Values are means±SE. Difference was found between the segments (P<0.001).
Grahic Jump Location
Morphometry of rat small intenstine in the no-load state (top) and zero-stress state (middle). The bottom plot shows the wall thickness to inner circumferential length ratio in no-load state. D: Duodenum; J: jejunum; I: ileum. Values are means±SE. Differences between the segments were found for all measures in no-load state (p<0.05), and for the wall thickness in zero-stress state (p<0.001). The ratio of wall thickness to ICL in no-load state differed between segments (P<0.001).
Grahic Jump Location
Biomechanical parameters in the duodenum (D), jejunum (J), and ileum (I). Values are means±SE. A, Opening angles in the duodenum, jejunum, and ileum (p<0.001 between segments). B, The residual strain was tensile (positive) at the serosal surface, and compressive (negative) at the mucosal surface and differed between segments (P<0.05 and P<0.001). C, the residual strain difference between the inner and outer surface. Significant variation was found between the segments (p<0.001), and D, the residual strain difference between the inner and outer surfaces per unit wall thickness also differed between segments with the highest values found in the duodenum (p<0.05).
Grahic Jump Location
Results from distension tests in duodenum (○), jejunum (□) and ileum (▵). Values are means±SE. The top graphs show the pressure-diameter (A) and pressure-longitudinal extension (B) data. In graph B the length at zero pressure is set to 0. The curves in C show the circumferential stress-strain relations in the duodenum, jejunum, and ileum in order from the left to the right, which indicate that the duodenal wall was stiffest and the ileum the softest in circumferential direction (p<0.05). D, In longitudinal direction, the curves for duodenum and jejunum were located to the left whereas for the ileum was located to the right. Hence, the ileum was softest in longitudinal direction (p<0.05).
Grahic Jump Location
Histological data in the duodenum (D), jejunum (J), and ileum (I). Values are means±SE. p-values are given in the text.




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