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TECHNICAL PAPERS: Fluids/Heat/Transport

Targeted Drug Aeroso Deposition Analysis for a Four-Generation Lung Airway Model With Hemispherical Tumors

[+] Author and Article Information
C. Kleinstreuer, Z. Zhang

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910

J Biomech Eng 125(2), 197-206 (Apr 09, 2003) (10 pages) doi:10.1115/1.1543548 History: Received December 01, 2001; Revised October 01, 2002; Online April 09, 2003
Copyright © 2003 by ASME
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References

Figures

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Schematic of a symmetric triple bifurcation airway model (generations G3-G6) with a hemispherical tumor
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Particle deposition patterns for cyclic inhalation as well as for the matching steady inhalation in a triple bifurcation airway model, where Stmatch=C(Stmean+Stmax),Rematch=C(Remean+Remax), and 0.48≤C≤0.53 for all smooth inhalation waveforms 16
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Mid-plane velocity vectors, axial velocity contours, and secondary vectors (upper half of cross-sectional views) as well as particle distributions and flow directions (lower half of cross-sectional views) at selected cross sections near the tumor for tumor Model 1 (r/R=1.0) at ReG3=463 and StG3=0.12
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Mid-plane velocity vectors, axial velocity contours, and secondary vectors (upper half of cross-sectional views) as well as particle distributions and flow directions (lower half of cross-sectional views) at selected cross sections near the tumor for tumor Model 1 (r/R=1.5) at ReG3=1882 and StG3=0.12
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Three-dimensional views of local particle deposition patterns around the tumor for Model 1 (r/R=1.25) at: (a) ReG3=463 and StG3=0.04; (b) ReG3=463 and StG3=0.12; (c) ReG3=1882 and StG3=0.04; and (d) ReG3=1882 and StG3=0.12
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Three-dimensional views of local particle deposition patterns around the tumor for Model 2 (r/R=1.25) at ReG3=1882 and StG3=0.12
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Three-dimensional views of local particle deposition patterns around the tumor for Model 3 (r/R=1.25) at ReG3=1882 and StG3=0.12
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Variations of DF-values on the tumor surface vs tumor size for Model 1.
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Inlet release positions of particles which land on the tumor surface (Normal Test Case).
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Demonstration of “controlled particle release” concept: (a) inlet release positions of particles for Controlled Test Case; (b) resulting particle deposition patterns for Model 1 (r/R=1.5) at ReG3=1882 and StG3=0.12; and (c) comparison of deposition fractions for different particle release cases (i.e., normal vs controlled), tumor sizes, and air-particle inlet conditions in terms of matching Reynolds and Stokes number pairs.

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