TECHNICAL PAPERS: Fluids/Heat/Transport

Analysis of Hemodynamic Fluid Phase Mass Transport in a Separated Flow Region

[+] Author and Article Information
Elizabeth M. Lutostansky

G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405

Gerhard Karner, Gerhard Rappitsch, Karl Perktold

Institute of Mathematics, Graz University of Technology, Graz, Austria

David N. Ku

G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0405 e-mail: david.ku@me.gatech.edu

J Biomech Eng 125(2), 189-196 (Apr 09, 2003) (8 pages) doi:10.1115/1.1543547 History: Received March 01, 2000; Revised November 01, 2002; Online April 09, 2003
Copyright © 2003 by ASME
Your Session has timed out. Please sign back in to continue.


Ku,  D. N., Giddens,  D. P., Zarins,  C. K., and Glagov,  S., 1985, “Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation,” Atherosclerosis, 5, pp. 293–302.
Caro,  C. G., Fitz-Gerald,  J. M., and Schroter,  R.C., 1971, “Atheroma and Arterial Wall Shear–Observation, Correlation and Proposal of a Shear Dependent Mass Transfer Mechanism for Atherogenesis,” Proc. R. Soc. Lond. Biol., 177, pp. 109–159.
Ma,  P., Li,  X., and Ku,  D. N., 1994, “Heat and Mass Transfer in a Separated Flow Region for High Prandtl and Schmidt Numbers Under Pulsatile Conditions,” Int. J. Heat Mass Transf., 37, pp. 2723–2736.
McIntire, L. V., and Tran-Son-Tay, R., 1989, “Concentration of Materials Released from Mural Platelet Aggregates: Flow Effects,” in Biomedical Engineering (Edited by W.-J. Yang and C.-J. Lee), Hemisphere Publ. Corp., NY, pp. 229-245.
Renkin, E. M., and Crone, C., 1996, “Microcirculation and Capillary Exchange,” in Comprehensive Human Physiology (edited by R. Gregor and U. Windhorst), Springer Verlag, Berlin, 1965–1979.
Wada, S., and Karino, T., 2000, “Computational Study on LDL Transfer from Flowing Blood to Arterial Walls,” in Clinical Application of Computational Mechanics to the Cardiovascular System (edited by T. Yamaguchi), Springer Verlag, Tokyo, pp. 157–173.
Karner,  G., Perktold,  K., and Zehentner,  H. P., 2001, “Computational Modeling of Macromolecule Transport in the Arterial Wall,” Computer Methods in Biomechanics and Biomedical Engineering,4, pp. 491–504.
Perktold,  K., 1987, “On Numerical Simulation of Three-Dimensional Physiological Flow Problems,” Ber. Math. Stat. Sektion, Forschungsges. Joanneum Graz. Nr.,280, 5.
Hilbert, D., 1987, “Ein Finite Element-Aufspaltungsverfahren zurnumerischem Lösung der Navier-Stokes-Gleichungen and seine Anwendung auf die Strömung in Rohren mit Elastischem Wänden,” Diss., TU-Graz.
Perktold,  K., Resch,  M., and Florian,  H., 1991, “Pulsatile Non-Newtonian Flow Characteristics in a Three-dimensional Human Carotid Bifurcation Model,” ASME J. Biomech. Eng.113, pp. 464–475.
Perktold, K., and Rappitsch, G., 1994, “Mathematical Modeling of Local Arterial Flow and Vessel Mechanics,” in Computational Methods for Fluid-Structure Interaction, (edited by J. M. Crolet and R. Ohayon), Pitman Research Notes in Methematics, Longman Scientific & Technical, NY, 306 , pp. 230–245.
Perktold,  K., and Rappitsch,  G., 1995, “Computer Simulation of Local Flood Flow and Vessel Mechanics in a Compliant Carotid Artery Bifurcation Model,” J. Biomech., 28, pp. 845–856.
Chorin,  A. J., 1968, “Numerical Solution of the Navier-Stokes Equation,” Math. Comput., 22, pp. 745–762.
Girault, H. G., and Raviart, P. A., 1986, “Finite Element Methods for Navier-Stokes Equations,” Springer Verlag, Berlin.
Rappitsch,  G., and Perktold,  K., 1996, “Computer Simulation of Convective Diffusion Processes in Large Arteries,” J. Biomech., 29, pp. 207–215.
Rappitsch,  G., and Perktold,  K., 1996, “Pulsatile Albumin Transport in Large Arteries: A Numerical Simulation Study,” ASME J. Biomech. Eng., 118, pp. 511–519.
Brooks,  A. N., and Hughes,  T. J. R., 1982, “Streamline Upwind/Petrov-Galerkin Formulations for Convection Dominated Flows with Particular Emphasis on the Incompressible Navier-Stokes Equations,” Comput. Methods Appl. Mech. Eng., 32, pp. 199–259.
Rappitsch, G., 1996, “Stable Finite Element Methods for Convection-Dominated Diffusion Processes and Application to Cardiovascular Transport Problems,” Ph.D. Thesis (in German), Technical University Graz.
Wada,  S., and Karino,  T., 1999, “Theoretical Study on Flow-Dependent Concentration Polarization of Low Density Lipoproteins at the Luminal Surface of a Straight Artery,” Biorheology, 36, pp. 207–223.
Fletcher,  D. F., Maskell,  S. J., and Patrick,  M. A., 1985, “Heat and Mass Transfer Computations for Laminar Flow in an Axisymmetric Sudden Expansion,” Comput. Fluids, 13, pp. 207–221.
Schoephoerster,  R. T., Oynes,  F., Nunez,  G., Kapadvanjwala,  M., and Dewanjee,  M. K., 1993, “Effects of Local Geometry and Fluid Dynamics on Regional Platelet Deposition on Artificial Surfaces,” Arterioscler. Thromb., 13, (12) pp. 1806–1813.
Ross,  R., , 1977, “Response to Injury and Atherogenesis,” Am. J. Pathol., 6, p. 75.


Grahic Jump Location
Wall concentration versus time in the sudden expansion region at the four sampling locations according to Fig. 1
Grahic Jump Location
Wall concentration in the sudden expansion: Concentration along the wall for different time steps
Grahic Jump Location
Concentration profiles in the sudden expansion region at the cross-sections corresponding to the four sampling locations according to Fig. 1 and to a location 5—at a distance of 66 upstream tube diameters from the expansion. The mark represents the position of the dividing streamline.
Grahic Jump Location
Wall shear stress, wall concentration and wall flux at the downstream end of the upstream tube and along the downstream tube (sudden expansion) wall. The vertical dashed line indicates the location of the expansion.
Grahic Jump Location
Schematic diagram of the sampling locations in the experimental axisymmetric sudden expansion
Grahic Jump Location
Schematic diagram of an imaginary hemisphere of fluid withdrawn from the sampling site illustrating the finite volume of the experimental sample
Grahic Jump Location
Axial flow velocity profiles in the sudden expansion region at the cross-sections corresponding to the four sampling locations according to Fig. 1



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In