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TECHNICAL PAPERS: Bone/Orthopedic

A Growth Mixture Theory for Cartilage With Application to Growth-Related Experiments on Cartilage Explants

[+] Author and Article Information
Stephen M. Klisch, Silvia S. Chen, Robert L. Sah

Department of Bioengineering, University of California at San Diego, La Jolla, CA

Anne Hoger

Department of Mechanical and Aerospace Engineering, University of California at San Diego, La Jolla, CA

J Biomech Eng 125(2), 169-179 (Apr 09, 2003) (11 pages) doi:10.1115/1.1560144 History: Received September 01, 2001; Revised December 01, 2002; Online April 09, 2003
Copyright © 2003 by ASME
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Figures

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Schematic of the major components of the solid extracellular matrix of articular cartilage.
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Physical and mathematical descriptions of cartilage growth for the special case when only proteoglycan molecules are deposited. See accompanying text for a full description.
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Model results that describe the kinematics of growth for developing bovine cartilage specimens. Mean ±S.E.M. results for fetal (F,n=6), newborn (N,n=8), and adult (A,n=7) groups. (+) indicates a significant difference between either N or A groups and the F group, (++) indicates a significant difference between N and A groups (ANOVA, Tukey post-hoc, p<0.05).
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CASE A model results that describe the evolution of the collagen material constants (λccc) for developing bovine cartilage specimens using the collagen stress equation (16). Mean ±S.E.M. results for fetal (F,n=6), newborn (N,n=8), and adult (A,n=7) groups. (+) indicates a significant difference between either N or A groups and the F group (ANOVA, Tukey post-hoc, p<0.05).
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CASE A model results that describe the evolution of the collagen material constants (μ̄c,H̄Ac) for developing bovine cartilage specimens using the collagen stress equation (18). Mean ± S.E.M. results for fetal (F,n=6), newborn (N,n=8), and adult (A,n=7) groups. (+) indicates a significant difference between either N or A groups and the F group (ANOVA, Tukey post-hoc, p<0.05).
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CASE A linear regression curves for the collagen material constants (μc,μ̄c) for the F/N/A groups, respectively. Both collagen material parameters were positively correlated (p<0.01) with collagen crosslink density γc (normalized by the average for the F group).
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Linear regression curves for the predicted solid matrix material constants (Ḡs,k̄s,Ēs) for the F/N/A groups, respectively. All three solid matrix material parameters were positively correlated (p<0.01) with collagen crosslink density γc (normalized by the average for the F group).

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