The Extent and Distribution of Cell Death and Matrix Damage in Impacted Chondral Explants Varies with the Presence of Underlying Bone

[+] Author and Article Information
J. A. Krueger, P. Thisse, B. J. Ewers, R. C. Haut

Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824

D. Dvoracek-Driksna, M. W. Orth

Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824

J Biomech Eng 125(1), 114-119 (Feb 14, 2003) (6 pages) doi:10.1115/1.1536654 History: Received July 01, 2001; Revised July 01, 2002; Online February 14, 2003
Copyright © 2003 by ASME
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Grahic Jump Location
In osteochondral explants, there was a significant decrease in the percentage of cell death following low rate of loading tests in the superficial (p=0.046) and middle zones (p=0.006) (+), and in the middle zone (p=0.041) following a high rate of loading test ( * ), compared to chondral explants.
Grahic Jump Location
Photographs of chondral explant cross-sections were taken after (a) low and (c) high rate of loading tests. Deeper fissures were found in chondral explants than osteochondral explants following both (b) low and (d) high rate of loading tests. Note that the superficial, intermediate and deep zones of cartilage have been highlighted along with the typical appearances of fissures in these tests.
Grahic Jump Location
Gross photographs were used to determine the average total fissure length for chondral explants following (a) low and (c) high rate impacts. Less fissuring was found in osteochondral explants after (b) low and (d) high rate of loading tests when compared to chondral explants.
Grahic Jump Location
Average stress-strain plots for cartilage and osteochondral explants were constructed following (a) low rate and (b) high rate of loading tests. Osteochondral explants had a shift to the left resulting in a stiffer response under compressive impact load for both rate of loading tests.




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