Strain Measurement in Coronary Arteries Using Intravascular Ultrasound and Deformable Images

[+] Author and Article Information
Alexander I. Veress

Department of Bioengineering, Department of Radiology, University of Utah, Salt Lake City, UT

Jeffrey A. Weiss, Richard D. Rabbitt

Department of Bioengineering, University of Utah, Salt Lake City, UT

Grant T. Gullberg

Department of Radiology, University of Utah Medical Center, Salt Lake City, UT

D. Geoffrey Vince

Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH

J Biomech Eng 124(6), 734-741 (Dec 27, 2002) (8 pages) doi:10.1115/1.1519279 History: Received August 01, 2001; Online December 27, 2002
Copyright © 2002 by ASME
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(A) Reference IVUS image of an unloaded ex vivo human left anterior descending (LAD) artery. This image was used as the template in the Warping analyses. The solid white line indicates the IVUS catheter, the solid black line indicates the lumen boundary and the dashed black line indicates the media/adventitia boundary. The target image (B) was created by deforming the template image using the deformation map from the forward FE solution (see text for details).
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(A) Unloaded finite element mesh; (B) Displaced mesh resulting from the internal pressure load imposed on the forward problem. The tether mesh has been removed from the figure for clarity. The pressure loading used in the forward problem is indicated by the arrows.
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Changes in spatial filter mask and penalty parameter with computational quasi-time. The penalty was steadily increased over the course of the analysis while the blurring was held constant through the first half of the analysis and then decreased over the second half. The * indicates that the Augmented Lagrangian iterations were completed on the final time step.
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(A) Green-Lagrange 1st Principal strain distribution for the forward problem; (B) Strain distribution for the Warping problem. The four comparison locations are shown by their numerical designations.
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Circumferential stretch distributions at the lumen and medial/adventitial boundary for the forward and Warping solutions as a function of circumferential location. The forward and Warping stretches at both locations show excellent agreement. The origin is at the 12 o’clock position of the arterial wall and radial position increases in a clockwise manner with respect to the lumen.
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Effect of increasing levels of additive noise on the appearance of the template image. (A) SNR=8, (B) SNR=4, (C) SNR=1, (D) SNR=0.5 and (E) SNR=0.1.
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Effect of SNR on accuracy of strain predictions at the four comparison locations. The strain predictions from Warping were relatively unaffected until the SNR reached a level of 0.1.




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