Injection of Highly Supersaturated Oxygen Solutions Without Nucleation

[+] Author and Article Information
J. Creech, V. Divino, W. Patterson, P. J. Zalesky

TherOx, Inc., 2400 Michelson Dr., Irvine, CA 92612

C. E. Brennen

California Institute of Technology, MC 104-44, Pasadena, CA 91125

J Biomech Eng 124(6), 676-683 (Dec 27, 2002) (8 pages) doi:10.1115/1.1519558 History: Received July 01, 2001; Revised June 01, 2002; Online December 27, 2002
Copyright © 2002 by ASME
Your Session has timed out. Please sign back in to continue.


Brereton,  G. J., Crilly,  R. J., and Spears,  J. R., 1998, “Nucleation in Small Capillary Tubes,” Chem. Phys., 230, p. 253.
Skripov, V. P., 1974, Metastable Liquids, John Wiley and Sons.
Brennen, C. E., 1995, “Cavitation and Bubble Dynamics,” Oxford University Press.
Griffith,  P., and Wallis,  G. D., 1960, “The Role of Surface Conditions in Nucleate Boiling,” Chem. Eng. Prog., Symp. Ser., 56, pp. 30–49.
Burkhard,  M. E., and Van Liew,  H. D., 1994, “Simulation of Exchanges of Multiple Gases in Bubbles in the Body,” Respiration Physiology, 95, pp. 131–145.
Schlichting, H., 1960, “Boundary Layer Theory (4th ed.),” McGraw-Hill Book Company.
Pananicolaou,  P. N., and List,  E. J., 1988, “Investigation of Round Vertical Turbulent Buoyant Jets,” J. Fluid Mech., 195, p. 341.
Schmidt, A. X., and List, H. L., 1962, “Material and Energy Balances,” Prentice-Hall.
Dack, M. R. J. (editor), 1975–76, “Solutions and Solubilities,” in “Techniques of Chemistry,” 8, John Wiley and Sons.


Grahic Jump Location
Photographs of the distal ends of typical capillaries formed from silica (left) and PEEK (right)
Grahic Jump Location
Frames from a normal video showing typical laminar (left) and turbulent jets (right) emerging from a 325 μm capillary
Grahic Jump Location
Six examples of high-speed video frames showing bubbles about to exit a particular 250 μm capillary. The distal end of the capillary is on the right.
Grahic Jump Location
Three examples of high-speed video frames showing the faint images of bubbles that have just emerged from a 325 μm capillary
Grahic Jump Location
Typical histogram of the axial bubble length, s, divided by the tube diameter, d. Note that bubbles with s/d<1 are roughly spherical while those with s/d>1 are tube-filling slugs. This particular histogram is for a BKH-coated silica capillary with diameter 250 μm operating with a 3.45 MPa O2 solution at a velocity of 3.4 m/s.
Grahic Jump Location
Chart showing the results of tests carried out to investigate nucleation caused by the onset of turbulent flow within the capillary. Horizontal lines show nucleating (solid lines) and non-nucleating (dashed lines) Reynolds number ranges for a number of different capillaries (with and without ethanolization) operated with various aqueous solutions of O2 and CO2 (saturation pressures shown). Onset of nucleation as the flow rate and Reynolds number was increased is shown by the two short vertical lines.



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In