Hydraulic Resistance and Permeability in Human Lumbar Vertebral Bodies

[+] Author and Article Information
Ruth S. Ochia

Rush Presbyterian-St. Luke’s Medical Center, Department of Orthopedic Surgery, 2242 W. Harrison, Suite 103, Chicago, IL 60612e-mail: rochia92@yahoo.com

Randal P. Ching

Applied Biomechanics Laboratory, Department of Mechanical Engineering, University of Washington, 501 Eastlake Ave., Suite 102, Seattle, WA 98109e-mail: rc@u.washington.edu

J Biomech Eng 124(5), 533-537 (Sep 30, 2002) (5 pages) doi:10.1115/1.1503793 History: Received February 01, 2001; Revised May 01, 2002; Online September 30, 2002
Copyright © 2002 by ASME
Your Session has timed out. Please sign back in to continue.


Carter,  D. R., and Hayes,  W. C., 1977, “The Compressive Behavior of Bone as a Two-phase Porous Structure,” J. Bone Jt. Surg., Am. Vol., 59, pp. 954–962.
Bryant,  J. D., 1983, “The Effect of Impact on the Marrow Pressure of Long Bones in Vitro,” J. Biomech., 16, pp. 659–665.
Bryant,  J. D., 1988, “On the Mechanical Function of Marrow in Long Bones,” Proc. Inst. Mech. Eng., Part H: J. Eng. Med., 17, pp. 55–58.
Swanson,  S. A., and Freeman,  M. A., 1966, “Is Bone Hydraulically Strengthened?,” Med. Biol. Eng. Comput., 4, pp. 433–438.
Pugh,  J. W., Rose,  R. M., and Radin,  E. L., 1973, “Elastic and Viscoelastic Properties of Trabecular Bone: Dependence on Structure,” J. Biomech., 6, pp. 475–485.
Kazarian,  L., and Graves,  G. A., 1977, “Compressive Strength Characteristics of the Human Vertebral Centrum,” Spine, 2, pp. 1–14.
Ochoa,  J. A., Heck,  D. A., Brandt,  K. D., and Hillberry,  B. M., 1991, “The Effect of Intertrabecular Fluid on Femoral Head Mechanics,” J. Rheumatol., 18, pp. 580–584.
Ochoa,  J. A., Sanders,  A. P., Heck,  D. A., and Hillberry,  B. M., 1991, “Stiffening of the Femoral Head Due to Inter-trabecular Fluid and Intraosseous Pressure,” J. Biomech. Eng., 113, pp. 259–262.
Ochoa, J. A. and Hillberry, B. M., 1992, “A Poroelastic Model for the Hydraulic Stiffening of Cancellous Bone,” 38th Annual Meeting, Orthopaedic Research Society, G. E. Freidlaender, ed., Rider Dickerson Inc., Washington, D. C., 17 (1), pp. 163.
Heck, D. A., Ochoa, J. A., Kiesler, T. W., Brandt, K. D., and Hillberry, B. M., 1991, “In-vivo Bone Hydraulics,” Transactions of the 37th Annual Meeting, Orthopaedic Research Society, B. Caterson, ed., Adept Printing Inc., Anaheim, CA, 16 , pp. 490.
Downey,  D. J., Simkin,  P. A., Lanzer,  W. L., and Matsen,  F. A., 1988, “Hydraulic Resistance: A Measure of Vascular Outflow Obstruction in Osteonecrosis,” J. Orthop. Res., 6, pp. 272–278.
Simkin,  P. A., Pickerell,  C. C., and Wallis,  W. J., 1985, “Hydraulic Resistance in Bones of the Canine Shoulder,” J. Biomech., 18, pp. 657–663.
Tran,  N. T., Watson,  N. A., Tencer,  A. F., Ching,  R. P., and Anderson,  P. A., 1995, “Mechanism of the Burst Fracture in the Thoracolumbar Spine. The Effect of Loading Rate,” Spine, 20, pp. 1984–1988.
Beaudoin,  A. J., Mihalko,  W. M., and Krause,  W. R., 1991, “Finite Element Modelling of Polymethylmethacrylate Flow Through Cancellous Bone,” J. Biomech., 24, pp. 127–136.
Grimm,  M. J., and Williams,  J. L., 1997, “Measurements of Permeability in Human Calcaneal Trabecular Bone,” J. Biomech., 30, pp. 743–745.
Hui,  P. W., Leung,  P. C., and Sher,  A., 1996, “Fluid Conductance of Cancellous Bone Graft as a Predictor for Graft-Host Interface Healing,” J. Biomech., 29, pp. 123–132.
Lim,  T. H., and Hong,  J. H., 2000, “Poroelastic Properties of Bovine Vertebral Trabecular Bone,” J. Orthop. Res., 18, pp. 671–677.
Nauman,  E. A., Fong,  K. E., and Keaveny,  T. M., 1999, “Dependence of Intertrabecular Permeability on Flow Direction and Anatomic Site,” Ann. Biomed. Eng., 27, pp. 517–524.
Ochoa, J. A. and Hillberry, B. M., 1992, “Permeability of Bovine Cancellous Bone,” 38th annual meeting, Orthopaedic Research Society, G. E. Freidlaender, ed., Rider Dickerson Inc., Washington, D.C., 17 (1), pp. 162.
Muskat, M., 1937, The Flow of Homogeneous Fluids Through Porous Media, McGraw-Hill, Inc., New York.
Bryant, J. D., David, T., Gaskell, P. H., King, S., and Lond, G., 1989, “Rheology of Bovine Bone Marrow,” Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 203 , pp. 71–75.
Carter,  D. R., and Hayes,  W. C., 1976, “Bone Compressive Strength: The Influence of Density and Strain Rate,” Science, 194, pp. 1174–1176.
Argoubi,  M., and Shirazi-Adl,  A., 1996, “Poroelastic Creep Response Analysis of a Lumbar Motion Segment in Compression,” J. Biomech., 29, pp. 1331–1339.
Lee,  C. K., Kim,  Y. E., Lee,  C. S., Hong,  Y. M., Jung,  J. M., and Goel,  V. K., 2000, “Impact Response of the Intervertebral Disc in a Finite-Element Model,” Spine, 25, pp. 2431–2439.
Carter,  J., Ching,  R., Mirza,  S., and Tencer,  A., 2000, “Canal Geometry Changes Associated With Axial-compressive Cervical Spine Fracture,” Spine, 25, pp. 46–54.
Ching, R., 1992, “Residual Stability in Thoracolumbar Spine Fractures: A Biomechanical Study,” Dissertation, University of Washington, Seattle, WA.
Willèn,  J., Lindahl,  S., Irstam,  L., Aldman,  B., and Nordwall,  A., 1984, “The Thoracolumbar Crush Fracture. An Experimental Study on Instant Axial Dynamic Loading: The Resulting Fracture Type and Its Stability,” Spine, 9, pp. 624–631.


Grahic Jump Location
An example radiograph used to measure vertebral cross-sectional area of vertebral bodies with dime in the center for scaling. Specimens shown are (CW from top) 5178-L5, 5331-L4, 5675-L4, and 5640-L4.
Grahic Jump Location
Schematic of resistance to flow apparatus, where MTS is the material testing machine. The specimen is attached to the potting plate with PMMA and the superior surface is exposed to the oil in the piston.
Grahic Jump Location
Pressure history for specimen 5675 at velocity 20 mm/sec overlaid with an exponential curve fit used to determine steady state pressure
Grahic Jump Location
Pressure-time histories for specimen 5675 for each of the 4 input velocities: 5, 10, 15, and 20 mm/sec
Grahic Jump Location
Pressure-flow relationship for 10 specimens for 4 different flows: 5.75, 11.48, 17.21, and 22.98 ml/sec



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In