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TECHNICAL PAPERS

Nanostructure, Effective Properties, and Deformation Pattern of the Cochlear Outer Hair Cell Cytoskeleton

[+] Author and Article Information
Alexander A. Spector, Mohammed Ameen, Aleksander S. Popel

Department of Biomedical Engineering and Center for Computational Medicine and Biology, Johns Hopkins University, 720 Rutland Ave., Baltimore, MD 21205

Panos G. Charalambides

Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250

J Biomech Eng 124(2), 180-187 (Mar 29, 2002) (8 pages) doi:10.1115/1.1448521 History: Received April 01, 2001; Revised November 01, 2001; Online March 29, 2002
Copyright © 2002 by ASME
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References

Figures

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(a) General view of the outer hair cell cytoskeleton and (b) fragment of the cytoskeleton showing its multiple-domain nanostructure, longer filaments and shorter crosslinks inside domain, and strips of the intermediate material between domains
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(a) Model of the domain with parallel filaments and inclined crosslinks and (b) model of the connection of neighboring domains: spring model in the case of side-by-side contact and double-truss model in the case of edge-to-edge contact
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Deformation of a patch representing the effective properties of the cytoskeleton under the action of (a) load in the circumferential direction (parallel to sides 2 and 4), (b) load in the longitudinal direction (parallel to sides 1 and 3), and (c) shear load; finite element discretization is shown for the domains and intermediate material; thick and thin lines correspond, respectively, to the deformed and undeformed states.
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Histograms of the anisotropic stiffness moduli of the outer hair cell cytoskeleton, including the mean values (μ) and standard deviations (σ); (a) modulus C11, (b) modulus C12, (c) modulus C13, (d) modulus C22, (e) modulus C23, and (f ) modulus C33

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