0
Research Papers

Influence of Experimental Protocols on the Mechanical Properties of the Intervertebral Disc in Unconfined Compression

[+] Author and Article Information
Maximilien Recuerda, Simon-Pierre Coté, Isabelle Villemure

 École Polytechnique, Montréal, Quebec, H3C 3A7, Canada; Centre de Recherche, CHU Sainte-Justine, Montréal, Quebec, H3T 1C5, Canada

Delphine Périé1

 École Polytechnique, Montréal, Quebec, H3C 3A7, Canada; Centre de Recherche, CHU Sainte-Justine, Montréal, Quebec, H3T 1C5, Canadadelphine.perie@polymtl.ca

1

Corresponding author.

J Biomech Eng 133(7), 071006 (Jul 18, 2011) (5 pages) doi:10.1115/1.4004411 History: Received March 05, 2011; Accepted June 01, 2011; Revised June 01, 2011; Published July 18, 2011; Online July 18, 2011

The lack of standardization in experimental protocols for unconfined compression tests of intervertebral discs (IVD) tissues is a major issue in the quantification of their mechanical properties. Our hypothesis is that the experimental protocols influence the mechanical properties of both annulus fibrosus and nucleus pulposus. IVD extracted from bovine tails were tested in unconfined compression stress-relaxation experiments according to six different protocols, where for each protocol, the initial swelling of the samples and the applied preload were different. The Young’s modulus was calculated from a viscoelastic model, and the permeability from a linear biphasic poroviscoelastic model. Important differences were observed in the prediction of the mechanical properties of the IVD according to the initial experimental conditions, in agreement with our hypothesis. The protocol including an initial swelling, a 5% strain preload, and a 5% strain ramp is the most relevant protocol to test the annulus fibrosus in unconfined compression, and provides a permeability of 5.0 ± 4.2e−14 m4 /N·s and a Young’s modulus of 7.6 ± 4.7 kPa. The protocol with semi confined swelling and a 5% strain ramp is the most relevant protocol for the nucleus pulposus and provides a permeability of 10.7 ± 3.1 e−14 m4 /N·s and a Young’s modulus of 6.0 ± 2.5 kPa.

FIGURES IN THIS ARTICLE
<>
Copyright © 2011 by American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.

References

Figures

Grahic Jump Location
Figure 1

Initial swelling conditions: No swelling, semiconfined swelling, and free swelling

Grahic Jump Location
Figure 2

Results for the annulus fibrosus, (a) coefficients of determination for all protocols, (b) Young’s modulus E (in kPa) calculated by the viscolestlatic model for all protocols, (c) permeability k (in 10−14 m4 /Ns) calculated by the BPVE model for all protocols

Grahic Jump Location
Figure 3

Results for the nucleus pulposus, (a) determination coefficients for all protocols, (b) Young’s modulus E (in kPa) calculated by the viscolestlatic model for all protocols, (c) permeability (in 10−14 m4 /Ns) calculated by the BPVE model for all protocols

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In