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TECHNICAL PAPERS

Virus Transmission Through Compromised Synthetic Barriers: Part II—Influence of Pore Geometry

[+] Author and Article Information
Bigyani Das, Matthew R. Myers

Center for Devices and Radiological Health, U.S. FDA, HFZ-132, 12725 Twinbrook Parkway, Rockville, MD 20852

J Biomech Eng 123(5), 513-518 (May 16, 2001) (6 pages) doi:10.1115/1.1394199 History: Received July 06, 2000; Revised May 16, 2001
Copyright © 2001 by ASME
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Figures

Grahic Jump Location
(a) Rate of virus transmission (based upon a normalized inlet concentration of 1 virus/ml) through a cylindrical pore of elliptical cross section. Pore height=1 μm;width=4 μm. Solid line: upper bound of transmission rate for both HIV, HBV. Dashed line: lower bound for HIV. Dotted line: lower bound for HBV. (b) Rate of virus transmission (based upon a normalized inlet concentration of 1 virus/ml) through a cylindrical pore of elliptical cross section. Pore height=5 μm;width=20 μm. Solid line: upper bound of transmission rate for both HIV, HBV. Dashed line: lower bound for HIV. Dotted line: lower bound for HBV. (c) Rate of virus transmission (based upon a normalized inlet concentration of 1 virus/ml) through a cylindrical pore of elliptical cross section. Pore height=20 μm;width=80 μm. Solid line: upper bound of transmission rate for both HIV, HBV. Dashed line: lower bound for HIV. Dotted line: lower bound for HBV.
Grahic Jump Location
Rate of HIV transmission (based upon a normalized inlet concentration of 1 virus/ml) through a cylindrical pore of elliptical cross section, as a function of pore shape. Pore height is held constant at 5 μm. Driving pressure gradients are 1000 dyns/cm3 (lower 2 curves) and 100,000 dyns/cm3 (upper 2 curves). Dotted line represents upper bound for transmission rate; solid line the lower bound.
Grahic Jump Location
Amount of PRD1 virus transmitted through laser-drilled holes in a latex condom. Open circles: model calculations based upon a circular cylinder pore geometry. Triangles: model calculations based upon an exponential-horn geometry. Darkened circles: experimental measurements.

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