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TECHNICAL PAPERS

Virus Transmission Through Compromised Synthetic Barriers: Part I—Effect of Unsteady Driving Pressures

[+] Author and Article Information
Matthew R. Myers, Bigyani Das

Center for Devices and Radiological Health, U.S. FDA, HFZ-132, 12725 Twinbrook Parkway, Rockville, MD 20852

J Biomech Eng 123(5), 506-512 (May 16, 2001) (7 pages) doi:10.1115/1.1394198 History: Received July 06, 2000; Revised May 16, 2001
Copyright © 2001 by ASME
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References

Figures

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Compromised barrier with initial virus concentration field and transmembrane pressure. Dashed line denotes interface near barrier surface upon which reaction-rate boundary condition is applied.
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First 50 cycles of virus flow under the influence of a simulated coital pressure gradient. Hole in condom is modeled as a circular cylinder of diameter 2 μm. Cycle period is 2 seconds.
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Virus concentration (normalized by the initial concentration inside the condom) as a function of location, during the second cycle. Concentration is plotted along a line coinciding with the axis of the pore through the condom, with coordinates 0 to 100 pertaining to the pore itself in units of pore radii, coordinates less than zero to the volume within the condom in front of the pore inlet, and coordinates above 100 the region beyond the pore outlet. Solid line: time in the cycle corresponding to maximum forward flow through the pore; dashed line: time of zero flow at end of forward cycle; dotted line: time of maximum reverse flow.
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Velocity vectors characterizing the jet of virus suspension exiting the pore at the time of maximum forward flow. Bottom horizontal line coincides with pore axis. Largest vectors shown have magnitude equal to the average speed within the pore, approximately 0.8 cm/s.
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Virus concentration (normalized by the initial concentration inside the condom) as a function of location outside the condom, for cycles 100 (solid line), 300 (dashed), and 500 (dotted). Concentration is plotted along a line coinciding with the axis of the pore through the condom, with coordinate 100 denoting the pore outlet in units of pore radii, and coordinates above 100 the region beyond the pore outlet. All curves pertain to the time in the cycle of maximum forward flow.
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Total amount of virus transmitted through the 2 μm pore, assuming an unsteady (solid line) transmembrane pressure and a steady (dotted line) pressure equal to the average of the unsteady pressure

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