Steady-State Pleural Fluid Flow and Pressure and the Effects of Lung Buoyancy

[+] Author and Article Information
Richard Haber, James B. Grotberg

Biomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109

Matthew R. Glucksberg

Biomedical Engineering Department, Northwestern University, Evanston, IL 60208

Giuseppe Miserocchi, Daniele Venturoli

Department of Experimental and Environmental Medicine, Università Milano-Bicocca, Monza, 20052 Italy

Massimo Del Fabbro

Department of Surgery and Dentistry, Università di Milano, Milano, 20142 Italy

Christopher M. Waters

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163

J Biomech Eng 123(5), 485-492 (Apr 25, 2001) (8 pages) doi:10.1115/1.1392317 History: Received November 30, 1999; Revised April 25, 2001
Copyright © 2001 by ASME
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Lung, pleural membranes, and pleural liquid for an animal in supine position
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Experimental apparatus and measurement system
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Model of pleural-fluid flow and lung buoyancy
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Streamlines for non-contact, steady-state pleural flow with γ=0.2, λ=0.3, and Λ=0.05
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Range of parameters for contact and non-contact solutions
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Measured, normalized pressure drop, ΔP/ΔPH, versus γ, from rabbit protocol. The data are for: (a) supine position, and (b) prone position, with significance levels of P<0.01 and P<0.08, respectively. The dotted lines are individual rabbits and the thick solid lines are mean±SD.
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Predicted, normalized pressure drop, ΔP/ΔPH, versus γ using the theory. Theoretical curves are calculated for different values of λ as indicated and Λ=0.05.
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Nondimensional pleural liquid turnover as a function of γ for three values of λ



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