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TECHNICAL PAPERS

Steady-State Pleural Fluid Flow and Pressure and the Effects of Lung Buoyancy

[+] Author and Article Information
Richard Haber, James B. Grotberg

Biomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109

Matthew R. Glucksberg

Biomedical Engineering Department, Northwestern University, Evanston, IL 60208

Giuseppe Miserocchi, Daniele Venturoli

Department of Experimental and Environmental Medicine, Università Milano-Bicocca, Monza, 20052 Italy

Massimo Del Fabbro

Department of Surgery and Dentistry, Università di Milano, Milano, 20142 Italy

Christopher M. Waters

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163

J Biomech Eng 123(5), 485-492 (Apr 25, 2001) (8 pages) doi:10.1115/1.1392317 History: Received November 30, 1999; Revised April 25, 2001
Copyright © 2001 by ASME
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References

Miserocchi,  G., and Negrini,  D., 1992, “Pleural Lymphatics as Regulators of Pleural Fluid Dynamics,” News Physiol. Sci., 6, pp. 153–158.
Miserocchi,  G., Negrini,  D., and Mortola,  J. P., 1986, “Comparative Features of Starling-Lymphatic Interaction at the Pleural Level in Mammals,” J. Appl. Physiol., 56, pp. 1151–1156.
Negrini, D., 1995, “Integration of Capillary, Interstitial and Lymphatic Function in the Pleural Space,” in: Interstitium, Connective Tissue and Lymphatics, R. K. Reed, N. G. McHale, J. L. Bert, C. P. Winlove, and G. A. Laine, eds., Portland Press, pp. 283–299.
Lai-Fook,  S. J., Price,  D. C., and Staub,  N. C., 1987, “Liquid Thickness vs. Vertical Pressure Gradient in a Model of the Pleural Space,” J. Appl. Physiol., 62, pp. 1747–1754.
Miserocchi,  G., Negrini,  D., Mariani,  E., and Passafaro,  M., 1983, “Reabsorption of a Saline- and Plasma-Induced Hydrothorax,” J. Appl. Physiol., 54, pp. 1574–1588.
Staub, N. C., Wiener-Kronish, J. P., and Albertine, K. H., 1985, “Transport Through the Pleura,” in: The Pleura in Health and Disease, J. Chrétien, J. Bignon, and A. Hirsch, eds., New York: Dekker, pp. 169–193.
Miserocchi, G., 1991, “Pleural Pressures and Fluid Transport,” in: The Lung: Scientific Foundations, R. G. Crystal and J. B. West, eds., New York: Raven Press, pp. 885–893.
Broaddus,  V. C., Wiener-Kronish,  J. P., and Staub,  N. C., 1990, “Clearance of Lung Edema Into the Pleural Space of Volume-Loaded Anesthetized Sheep,” J. Appl. Physiol., 68, pp. 2623–2630.
Negrini,  D., Venturoli,  D., Townsley,  M. I., and Reed,  R. K., 1994, “Permeability of Parietal Pleura to Liquid and Proteins,” J. Appl. Physiol., 76, pp. 627–663.
Negrini, D., 1993, “Integration of the Capillary, Interstitial and Lymphatic Function in the Pleural Space,” Abst. No. 266.3. Proc. XXXII Cong. Internat. Union Physiol. Sci.
Lai-Fook,  S. J., Brown,  L. V., Maudgalya,  V. S., Knapp,  C. F., and Ganesan,  S., 1991, “Effect of Increased Acceleration on Regional Pleural Pressure in Dogs,” J. Appl. Physiol., 71, pp. 611–619.
Guy,  H. J. B., Prisk,  G. K., Elliott,  A. R., Deutschman,  R. A., and West,  J. B., 1994, “Inhomogeneity of Pulmonary Ventilation During Sustained Microgravity as Determined by Single-Breath Washouts,” J. Appl. Physiol., 76, pp. 1719–1729.
Hills,  B. A., 1992, “Graphite-like Lubrication of Mesothelium by Oligolamellar Pleural Surfactant,” J. Appl. Physiol., 73, pp. 1034–1039.
Mariassy,  A. T., and Wheeldon,  E. B., 1985, “The Pleura: A Combined Light Microscopic, Scanning and Transmission Electron Microscopic Study in the Sheep. I. Normal Pleura,” Exp. Lung Res., 4, pp. 293–313.
Lai-Fook,  S. J., and Kaplowitz,  M. R., 1985, “Pleural Space Thickness In Situ by Light Microscopy in Five Mammalian Species,” J. Appl. Physiol., 59, pp. 603–610.
Albertine,  K. J., Weiner-Kronish,  J. P., Bastacky,  J., and Staub,  N. C., 1991, “No Evidence for Mesothelial Cell Contact Across the Costal Pleural Space of Sheep,” J. Appl. Physiol., 70, pp. 123–134.
Grotberg,  J. B., and Glucksberg,  M. R., 1994, “A Buoyancy-Driven Squeeze-Film Model of Intrapleural Fluid Dynamics: Basic Concepts,” J. Appl. Physiol., 77, pp. 1555–1561.
Urmey,  W. F., Troyer,  A. D., Kelly,  K. B., and Loring,  S. H., 1988, “Pleural Pressures Increases During Inspiration in the Zone of Apposition of Diaphragm to Rib Cage,” J. Appl. Physiol., 65, pp. 2207–2212.
Goodman, G., 1985, The Pharmacological Basis of Therapeutics, MacMillan Publishing Company, New York.
Mates,  E. A., Jackson,  J. C., Hildebrandt,  J., Truog,  W. E., Standaert,  T. A., and Hlastala,  M. P., 1994, “Respiratory Gas Exchange and Inert Gas Retention During Partial Liquid Ventilation,” Adv. Exp. Med. Biol., 361, pp. 427–435.
Leach,  C. L., Greenspan,  J. S., Rubenstein,  S. D., Shaffer,  T. H., Wolfson,  M. R., Jackson,  J. C., DeLemos,  R., and Fuhrman,  B. P., 1996, “Partial Liquid Ventilation With Perflubron in Premature Infants With Severe Respiratory Distress Syndrome. The LiquiVent Study Group [see comments],” N. Engl. J. Med., 335, pp. 761–767.
Tutuncu,  A. S., Akpir,  K., Mulder,  P., Erdmann,  W., and Lachmann,  B., 1993, “Intratracheal Perfluorocarbon Administration as an Aid in the Ventilatory Management of Respiratory Distress Syndrome,” Anesthesiology, 79, pp. 1083–1093.
Jackson,  J. C., Standaert,  T. A., Truog,  W. E., and Hodson,  W. A., 1994, “Full-Tidal Liquid Ventilation With Perfluorocarbon for Prevention of Lung Injury in Newborn Non-human Primates,” Artif. Cells Blood Substit Immobil Biotechnol., 22, pp. 1121–1132.
Hirschl,  R. B., Parent,  A., Tooley,  R., Shaffer,  T., Wolfson,  M., and Bartlett,  R. H., 1994, “Lung Management With Perfluorocarbon Liquid Ventilation Improves Pulmonary Function and Gas Exchange During Extracorporeal Membrane Oxygenation (ECMO),” Artif. Cells Blood Substit. Immobil. Biotechnol., 22, pp. 1389–1396.
Negrini,  D., Capelli,  C., Morini,  M., and Miserocchi,  G., 1987, “Gravity-Dependent Distribution of Parietal Subpleural Interstitial Pressure,” J. Appl. Physiol., 63, pp. 1912–1918.
Negrini,  D., and Miserocchi,  G., 1989, “Size-Related Differences in Parietal Extrapleural and Pleural Liquid Pressure Distribution,” J. Appl. Physiol., 67, pp. 1967–1972.
Miserocchi,  G., Kelly,  S., and Negrini,  D., 1988, “Pleural and Extrapleural Interstitial Liquid Pressure Measured by Cannulas and Micropipettes,” J. Appl. Physiol., 65, pp. 555–562.
Negrini,  D., Townsley,  M. I., and Taylor,  A. E., 1990, “Hydraulic Conductivity of Canine Parietal Pleura In Vivo,” J. Appl. Physiol., 69, pp. 438–442.
Miserocchi,  G., Venturoli,  D., Negrini,  D., and Fabbro,  M. D., 1993, “Model of Pleural Fluid Turnover,” J. Appl. Physiol., 75, pp. 1798–1806.
Butler,  J. P., Huang,  J., Loring,  S. H., Lai-Fook,  S. J., Wang,  P. M., and Wilson,  T. A., 1995, “Model for a Pump That Drives Circulation of Pleural Fluid,” J. Appl. Physiol., 78, pp. 23–29.
Wang,  P. M., and Lai-Fook,  S. J., 1994, “Effects of Mechanical Ventilation on Pleural Liquid Dynamics in Rabbits,” Ann. Biomed. Eng., 22, p. 11.
Waters,  C. M., Glucksberg,  M. R., Depaola,  N., Chang,  J. L., and Grotberg,  J. B., 1996, “Shear Stress Alters Pleural Mesothelial Cell Permeability in Culture,” J. Appl. Physiol., 81, pp. 448–458.
Lai-Fook,  S. J., and Rodarte,  J. R., 1991, “Pleural Pressure Distribution and Its Relationship to Lung Volume and Interstitial Pressure,” J. Appl. Physiol., 70, pp. 967–978.
Grotberg,  J., Haber,  R., and Glucksberg,  M., 1996, “An Extended Model of Intrapleural Fluid Flow and Transport,” FASEB J., 10, p. A806.
Allen,  S. J., Fraser,  R. E., Laurent,  U. B. G., Reed,  R. K., and Laurent,  T. C., 1992, “Turnover of Hyaluronan in the Rabbit Pleural Space,” J. Appl. Physiol., 73, pp. 1457–1460.
Agostoni,  E., and Zocchi,  L., 1990, “Solute-Coupled Liquid Absorption From the Pleural Space,” Respir. Physiol., 81, pp. 19–27.
Bermudez,  E., Everitt,  J., and Walker,  C., 1990, “Expression of Growth Factor and Growth Factor Receptor RNA in Rat Pleural Mesothelial Cells in Culture,” Exp. Cell Res., 190, pp. 91–98.
Waters,  C. M., Chang,  J. Y., Glucksberg,  M. R., DePaola,  N., and Grotberg,  J. B., 1997, “Mechanical Forces Alter Growth Factor Release by Pleural Mesothelial Cells,” Am. J. Physiol.-Lung Cell. Mol. Physiol., 16, pp. L552–L557.
Kuwahara,  M., Kuwahara,  M., and Suzuki,  N., 1992, “Production of Endothelin-1 and Big-Endothelin-1 by Pleural Mesothelial Cells,” FEBS Lett., 298, pp. 21–24.
DePaola,  N., Waters,  C. M., Glucksberg,  M. R., and Grotberg,  J. B., 1995, “Shear Stress Stimulates Prostacyclin Production by Cultured Pleural Mesothelial Cells,” FASEB J., 9, p. A717.
Charlwood,  P. A., 1952, “Sedimentation and Diffusion of Human Albumins,” Biochem. J., 51, pp. 113–118.
Cussler, E. L., 1984, Diffusion Mass Transfer in Fluid Systems, Cambridge University Press, Cambridge.
Akeley,  D. F., and Gosting,  L. J., 1953, “Diffusion of Mixed Solutes With the Guoy Diffusiometer,” J. Am. Chem. Soc., 75, pp. 5685–5696.

Figures

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Lung, pleural membranes, and pleural liquid for an animal in supine position
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Experimental apparatus and measurement system
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Model of pleural-fluid flow and lung buoyancy
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Streamlines for non-contact, steady-state pleural flow with γ=0.2, λ=0.3, and Λ=0.05
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Range of parameters for contact and non-contact solutions
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Measured, normalized pressure drop, ΔP/ΔPH, versus γ, from rabbit protocol. The data are for: (a) supine position, and (b) prone position, with significance levels of P<0.01 and P<0.08, respectively. The dotted lines are individual rabbits and the thick solid lines are mean±SD.
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Predicted, normalized pressure drop, ΔP/ΔPH, versus γ using the theory. Theoretical curves are calculated for different values of λ as indicated and Λ=0.05.
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Nondimensional pleural liquid turnover as a function of γ for three values of λ

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