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TECHNICAL PAPERS

Cryosurgery of Normal and Tumor Tissue in the Dorsal Skin Flap Chamber: Part II—Injury Response

[+] Author and Article Information
Nathan E. Hoffmann

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455

John C. Bischof

Departments of Biomedical Engineering, Mechanical Engineering, and Urologic Surgery, University of Minnesota, Minneapolis, MN 55455

J Biomech Eng 123(4), 310-316 (Feb 27, 2001) (7 pages) doi:10.1115/1.1385839 History: Received July 14, 1999; Revised February 27, 2001
Copyright © 2001 by ASME
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References

Figures

Grahic Jump Location
Fluorescent image of the vasculature of normal tissue labeled with FITC-labeled dextran at day 3 after sham cryosurgery (A) and at 3 days (B) and 7 days (C) post cryosurgery. The right and left sides of the image are 1.5 mm and 4.8 mm from the center of the chamber, respectively. No fluorescence is visible to the right of the image toward the probe (Probe), and normal vasculature continues to the left of the image toward the edge of the chamber (Edge). S denotes the edge of the static zone. Radial distances (with 0 being the center of the chamber) are marked above the image in mm. Scale bar=200 μm.
Grahic Jump Location
Fluorescent image of the vasculature of tumor tissue labeled with FITC-labeled dextran at day 3 after sham cryosurgery (A) and at 3 days (B) and 7 days (C) post cryosurgery. The right and left sides of the image are 1.5 mm and 4.8 mm from the center of the chamber, respectively. No fluorescence is visible to the right of the image toward the probe (Probe), and normal vasculature continues to the left of the image toward the edge of the chamber (Edge). S denotes the edge of the static zone. Radial distances (with 0 being the center of the chamber) are marked above the image in mm. Scale bar=200 μm.
Grahic Jump Location
Histologic appearance of the histology of normal tissue labeled with H+E at 3 days post cryosurgery to show the features seen in all tissues, proceeding outward from the center of the lesion: central necrosis (A), a band of inflammation (dark spots are nuclei of inflammatory cells) (B), a clear zone between the infiltration and the vessel thrombosis (C), vessel dilation and thrombosis (thrombotic vessel interior marked by * ) (D). The tissue morphology outside the lesion (E) was comparable to that of tissue treated with sham cryosurgery (F). Scale bar=100 μm.
Grahic Jump Location
Histologic appearance of the histology of tumor tissue labeled with H+E at 3 days post cryosurgery to show the features seen in all tissues, proceeding outward from the center of the lesion: central necrosis (A), a band of inflammation (dark spots are nuclei of inflammatory cells) (B), a clear zone between the infiltration and the vessel thrombosis (C), vessel dilation and thrombosis (thrombotic vessel interior marked by * ) (D). The tumor cell morphology outside the lesion (E) was comparable to that of tissue treated with sham cryosurgery (F). Scale bar=100 μm.

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