Cryosurgery of Normal and Tumor Tissue in the Dorsal Skin Flap Chamber: Part I—Thermal Response

[+] Author and Article Information
Nathan E. Hoffmann

Department of Biomedical Engineering University of Minnesota, Minneapolis, MN 55455

John C. Bischof

Departments of Biomedical Engineering, Mechanical Engineering, and Urologic Surgery University of Minnesota, Minneapolis, MN 55455

J Biomech Eng 123(4), 301-309 (Feb 27, 2001) (9 pages) doi:10.1115/1.1385838 History: Received July 14, 1999; Revised February 27, 2001
Copyright © 2001 by ASME
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Grahic Jump Location
A schematic of one frame of the dorsal skin flap chamber that was implanted into the Copenhagen rat. A frontal view is depicted in (A), and a cross-sectional view in (B) to emphasize the bevelled window holding area.
Grahic Jump Location
A cross-sectional schematic of cryosurgery in the dorsal skin flap chamber
Grahic Jump Location
A cross-sectional schematic of the geometry used in DSFC modeling
Grahic Jump Location
Plot of temperature recorded by thermocouples versus time for a typical DSFC cryosurgery
Grahic Jump Location
Plot of the tissue temperature measurements versus thermocouple bead sizes (data points) for the in vitro experiment investigating thermocouple conduction. Also depicted is the least-squares fit of the data to a linear function (Eq. (1)), lines). Error bars (most not large enough to appear on graph) are at 95 percent and based on equipment error and experimental variance.
Grahic Jump Location
Plot of the tissue end temperature versus radius from the center of the chamber for cryosurgery in the DSFC. Tissue end temperatures were obtained from the corrected thermocouple measurement (squares), the two-dimensional transient solution using the average probe thermal history (- - - -), and the one-dimensional steady cylindrical solution (–). Error bars (±95 percent CI) are based on Eq. (14).



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