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TECHNICAL PAPERS

Cryosurgery of Normal and Tumor Tissue in the Dorsal Skin Flap Chamber: Part I—Thermal Response

[+] Author and Article Information
Nathan E. Hoffmann

Department of Biomedical Engineering University of Minnesota, Minneapolis, MN 55455

John C. Bischof

Departments of Biomedical Engineering, Mechanical Engineering, and Urologic Surgery University of Minnesota, Minneapolis, MN 55455

J Biomech Eng 123(4), 301-309 (Feb 27, 2001) (9 pages) doi:10.1115/1.1385838 History: Received July 14, 1999; Revised February 27, 2001
Copyright © 2001 by ASME
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References

Hoffmann,  N. E., and Bischof,  J. C., 2001, “Cryosurgery of Normal and Tumor Tissue in the Dorsal Skin Flap Chamber: Part II — Injury Response,” ASME J. Biomech. Eng., 123, this issue, pp. 310–316.
Cooper,  T. E., and Petrovic,  W. K., 1974, “An Experimental Investigation of the Temperature Field Produced by a Cryosurgical Cannula,” ASME J. Heat Transfer, 96, pp. 415–420.
Rewcastle,  J. C., Sandison,  G. A., Hahn,  L. J., Saliken,  J. C., McKinnon,  J. G., and Donnelly,  B. J., 1998, “A Model for the Time-Dependent Thermal Distribution Within an Iceball Surrounding a Cryoprobe,” Phys. Med. Biol., 43, No. 12, pp. 3519–3534.
Budman,  H., Shitzer,  A., and Del Guidice,  S., 1986, “Investigation of Temperature Fields Around Embedded Cryoprobes,” ASME J. Biomech. Eng., 108, pp. 42–48.
Hong,  J.-S., Wong,  S., Pease,  G., and Rubinsky,  B., 1994, “MR Imaging Assisted Temperature Calculations During Cryosurgery,” Magn. Reson. Imaging, 12, No. 7, pp. 1021–1031.
Bischof,  J. C., Bastacky,  J., and Rubinsky,  B., 1992, “An Analytical Study of Cryosurgery in the Lung,” ASME J. Biomech. Eng., 114, pp. 467–472.
Gori, F., 1981, “On Heat Transfer in Non-Living Materials Around a Cryosurgical Probe,” in: Numerical Methods in Thermal Problems, Pineridge Press, Venice, Italy.
Rubinsky,  B., and Shitzer,  A., 1976, “Analysis of a Stefan-Like Problem in a Biological Tissue Around a Cryosurgical Probe,” ASME J. Heat Transfer, 98, pp. 514–519.
Smith, D. J., Devireddy, R. V., and Bischof, J. C., 1999, “Prediction of Thermal History and Interface Propagation During Freezing in Biological Systems—Latent Heat and Temperature-Dependent Property Effects,” in: Proc. 54th ASME/JSME Joint Thermal Engineering Conference, San Diego, CA, AJTE 99-6520.
Rabin,  Y., and Shitzer,  A., 1997, “Combined Solution of the Inverse Stefan Problem for Successive Freezing/Thawing in Nonideal Biological Tissues,” ASME J. Biomech. Eng., 119, pp. 146–152.
Rabin,  Y., and Shitzer,  A., 1998, “Numerical Solution of the Multidimensional Freezing Problem During Cryosurgery,” ASME J. Biomech. Eng., 120, pp. 32–37.
Gage,  A. A., Caruana,  J. A., and Garamy,  G., 1983, “A Comparison of Instrument Methods of Monitoring Freezing in Cryosurgery,” J. Dermatol. Surg. Oncol., 9, No. 3, pp. 209–214.
Rabin,  Y., 1998, “Uncertainty in Temperature Measurements Using Thermocouples,” Cryo-Letters, 19, No. 4, pp. 213–224.
Papenfuss,  H. D., Gross,  J. F., Intaglietta,  M., and Treese,  F. A., 1979, “A Transparent Access Chamber for the Rat Dorsal Skin Fold,” Microvasc. Res., 18, No. 3, pp. 311–318.
Gaber,  M. H., Wu,  N. Z., Hong,  K., Huang,  S. K., Dewhirst,  M. W., and Papahadjopoulos,  D., 1996, “Thermosensitive Liposomes: Extravasation and Release of Contents in Tumor Microvascular Networks,” Int. J. Radiat. Oncol., Biol., Phys., 36, No. 5, pp. 1177–1187.
Aggarwal,  S. J., Shah,  S. J., Diller,  K. R., and Baxter,  C. R., 1989, “Fluorescence Digital Microscopy of Interstitial Macromelecular Diffusion in Burn Injury,” Comput. Biol. Med., 19, No. 4, pp. 245–261.
Yuan,  F., Leunig,  M., Berk,  D. A., and Jain,  R. K., 1993, “Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice,” Microvasc. Res., 45, No. 3, pp. 269–89.
Endrich,  B., Laprell-Moschner,  C., Brendel,  W., and Messmer,  K., 1982, “Effects of Prolonged Cold Injury on the Subcutaneous Microcirculation of the Hamster. I. Technique, Morphology and Tissue Oxygenation,” Res. Exp. Med., 181, No. 1, pp. 49–61.
Diller,  K. R., and Hayes,  L. J., 1991, “Analysis of Tissue Injury by Burning: Comparison of in Situ and Skin Flap Models,” Int. J. Heat Mass Transf., 34, No. 6, pp. 1393–1406.
Gross,  J. F., Roemer,  R., Dewhirst,  M., and Meyer,  T., 1982, “A Uniform Thermal Field in a Hyperthermia Chamber for Microvascular Studies,” Int. J. Heat Mass Transf., 25, pp. 1313–1320.
Bischof,  J. C., Smith,  D. J., Pazhayannur,  P. V., Manivel,  C., Hulbert,  J., and Roberts,  K. P., 1997, “Cryosurgery of Dunning AT-1 Rat Prostate Tumor: Thermal, Biophysical and Viability Response at the Cellular and Tissue Level,” Cryobiology, 34, pp. 42–69.
Smith,  D. J., Fahssi,  W. M., Swanlund,  D. J., and Bischof,  J. C., 1999, “A Parametric Study of Freezing Injury in AT-1 Rat Prostate Tumor Cells,” Cryobiology, 39, pp. 13–28.
Fennema, O. R., Powrie, W. D., and Marth, E. H., 1973, Low Temperature Preservation of Food and Living Matter, Marcel Dekker, New York.
Devireddy,  R. V., Smith,  D. J., and Bischof,  J. C., 1999, “Mass Transfer During Freezing in Rat Prostate Tumor Tissue,” AIChE J., 45, No. 3, pp. 639–654.
Reinoso,  R. F., Telfer,  B. A., and Rowland,  M., 1997, “Tissue Water Content in Rats Measured by Desiccation,” J. Pharmacol. Toxicol. Methods, 38, No. 2, pp. 87–92.
Alexiades, A., and Solomon, A. D., 1993, “Formulation of the Stefan Problem,” in: Mathematical Modeling of Melting and Freezing Processes, Hemisphere Publishing, Washington, pp. 6–26.
Guide to Plastics, 1987, Modern Plastics Publication, McGraw-Hill New York.
Lunardini, V., 1981, “Finite Difference Methods for Freezing and Thawing,” in: Heat Transfer in Cold Climates, Van Nostrand Reinhold, Co., New York.
Voller,  V. R., and Swaminathan,  C. R., 1993, “Treatment of Discontinuous Thermal Conductivity in Control-Volume Solutions of Phase Change Problems,” Numer. Heat Transfer, 24, pp. 161–180.
Burton,  M. A., Kelleher,  D. K., Gray,  B. N., and Morgan,  C. K., 1990, “Effect of Temperature on Liver Tumour Blood Flow,” Eur. J. Cancer, 26, p. 999.
Cooper,  T. E., and Trezek,  G. J., 1971, “Rate of Lesion Growth Around Spherical and Cylindrical Cryoprobes,” Cryobiology, 7, pp. 183–190.
Hayes,  L. J., Diller,  K. R., Chang,  H. J., and Lee,  H. S., 1988, “Prediction of Local Cooling Rates and Cell Survival During the Freezing of a Cylindrical Specimen,” Cryobiology, 25, No. 1, pp. 67–82.
Rabin,  Y., 2000, “The Effect of Temperature-Dependent Thermal Conductivity in Heat Transfer Simulations of Frozen Biomaterials,” Cryo-Letters, 21, No. 3, pp. 163–170.
Bevington, P. R., and Robinson, D. K., 1992, “Error Analysis,” in: Data Reduction and Error Analysis for the Physical Sciences, 2nd ed., McGraw-Hill, New York, pp. 38–48.
Hayes,  L. J., and Diller,  K. R., 1983, “Implementation of Phase Change in Numerical Models of Heat Transfer,” J. Energy Resour. Technol., 105, pp. 431–435.

Figures

Grahic Jump Location
A schematic of one frame of the dorsal skin flap chamber that was implanted into the Copenhagen rat. A frontal view is depicted in (A), and a cross-sectional view in (B) to emphasize the bevelled window holding area.
Grahic Jump Location
A cross-sectional schematic of cryosurgery in the dorsal skin flap chamber
Grahic Jump Location
A cross-sectional schematic of the geometry used in DSFC modeling
Grahic Jump Location
Plot of temperature recorded by thermocouples versus time for a typical DSFC cryosurgery
Grahic Jump Location
Plot of the tissue temperature measurements versus thermocouple bead sizes (data points) for the in vitro experiment investigating thermocouple conduction. Also depicted is the least-squares fit of the data to a linear function (Eq. (1)), lines). Error bars (most not large enough to appear on graph) are at 95 percent and based on equipment error and experimental variance.
Grahic Jump Location
Plot of the tissue end temperature versus radius from the center of the chamber for cryosurgery in the DSFC. Tissue end temperatures were obtained from the corrected thermocouple measurement (squares), the two-dimensional transient solution using the average probe thermal history (- - - -), and the one-dimensional steady cylindrical solution (–). Error bars (±95 percent CI) are based on Eq. (14).

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