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TECHNICAL PAPERS

Specific Hydraulic Conductivity of Corneal Stroma as Seen by Quick-Freeze/Deep-Etch

[+] Author and Article Information
Darryl Overby, Jeffrey Ruberti, Mark Johnson

MIT, Cambridge, MA 02138

Haiyan Gong, Thomas F. Freddo

Boston University School of Medicine, Boston, MA 02215

J Biomech Eng 123(2), 154-161 (Oct 01, 2000) (8 pages) doi:10.1115/1.1351888 History: Received January 01, 2000; Revised October 01, 2000
Copyright © 2001 by ASME
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Figures

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ε′ and α′ /(πα/4) computed for randomly placed (noninterpenetrating) spheres that were numerically projected on a two-dimensional surface as a function of αDf /4ε with ε=0.8. Squares are numerical results for ε′ , circles for α′ /(πα/4). Error bars represent standard error. The solid line is prediction of equation (4a); the dashed line is prediction of equation (4b) with Dp=(3π/2)(1−ε)/α.
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(a) Conventional transmission electron micrograph of bovine corneal stroma with characteristic collagen banding pattern, (b) quick-freeze/deep-etch micrograph of bovine corneal stroma. Note the enhanced resolution of the interfibrillar structures; bars: 50 nm.
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(a) Typical interfibrillar network chosen for specific hydraulic conductivity analysis; (b) high threshold image of open-spaces available for fluid flow that include 32.8 percent of the pixels (shown in white: pixel value >165: arbitrary units); (c) low threshold image of open-spaces available for fluid flow that include 17.8 percent of the pixels (pixel value >210). ×345,000; bar: 50 nm
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Gray-scale histogram of the interfibrillar region shown in Fig. 3. Higher pixel values correspond to darker spaces. The high and low threshold limits are shown with the pixels on the right of each limit being defined as contributing to the open-spaces available for fluid flow.
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Interfibrillar porosity (ε) of the hydrodynamically significant spaces as a function of depth-of-field (Df). Two families of curves are shown, one for a low threshold level, the other high. For each threshold level, the shaded region represents the influence of particle shape [equation (5)]. The arrows indicate the minimum and maximum values of Df.
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Interfibrillar specific surface (α) of the hydrodynamically significant spaces as a function of depth-of-field (Df). Labels as in Fig. 5.
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Interfibrillar specific hydraulic conductivity (Ki) as a function of depth-of-field (Df). Labels as in Fig. 5.

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