0
TECHNICAL PAPERS

Hydrodynamic Modeling of Cerebrospinal Fluid Motion Within the Spinal Cavity

[+] Author and Article Information
Francis Loth

Department of Mechanical Engineering, University of Illinois at Chicago, Chicago, IL 60607

M. Atif Yardimci

Advanced Engineering Design Center, CRTS, Baxter International, Round Lake, IL 60606

Noam Alperin

Department of Radiology, University of Illinois at Chicago, Chicago, IL 60607

J Biomech Eng 123(1), 71-79 (Sep 13, 2000) (9 pages) doi:10.1115/1.1336144 History: Received September 13, 1999; Revised September 13, 2000
Copyright © 2001 by ASME
Your Session has timed out. Please sign back in to continue.

References

Segal, M. B., 1992, Barriers and Fluids of the Eye and Brain, CRC Press, Boca Raton, FL.
Bering,  R. A., 1962, “Circulation of Cerebrospinal Fluid: Demonstration of Choroid Plexuses as the Generator of the Force for Flow of Fluid and Ventricular Enlargement,” J. Neurosurg., 18, pp. 405–413.
Du Boulay,  G. H., 1966, “Pulsatile Movements in the CSF Pathways,” Br. J. Radiol., 39, pp. 255–262.
Dunbar,  H. S., Guthrie,  T. C., and Karpell,  B., 1966, “A Study of the Cerebrospinal Fluid Pulse Wave,” Arch. Neurol., 14, pp. 624–630.
Feinberg,  D. A., and Mark,  A. S., 1987, “Human Brain Motion and Cerebrospinal Fluid Circulation Demonstrated With MR Velocity Imaging,” Radiology, 163, pp. 793–799.
Enzmann, D. R., and Pelc, N. J., 1993, “Cerebrospinal Fluid Flow Measured by Phase-Contrast Cine MR,” AJNR American J. Neuroradiology, 14, pp. 1301–1307.
Winkler,  P., 1994, “Cerebrospinal Fluid Dynamics in Infants Evaluated With Color Doppler US and Spectral Analysis: Respiratory Versus Arterial Synchronization,” Radiology, 192, pp. 423–430.
Winkler,  P., 1994, “Cerebrospinal Fluid Dynamics in Infants Evaluated With Echographic Color-Coded Flow Imaging,” Radiology, 192, pp. 431–437.
Bhadelia,  R. A., Bogdan,  A. R., and Wolpert,  S. M., 1995, “Analysis of Cerebrospinal Fluid Flow Waveforms With Gated Phase-Contrast MR Velocity Measurements,” AJNR Am. J. Neuroradiol., 16, pp. 389–400.
Henry-Feugas,  M. C., Idy-Peretti,  I., Blanchet,  B., Hassine,  D., Zannoli,  G., and Schouman-Claeys,  E., 1993, “Temporal and Spatial Assessment of Normal Cerebrospinal Fluid Dynamics With MR Imaging,” Magn. Reson. Imaging, 11, pp. 1107–1118.
Gideon,  P., Sorensen,  P. S., Thomsen,  C., Stahlberg,  F., Gjerris,  F., and Henriksen,  O., 1994, “Assessment of CSF Dynamics and Venous Flow in the Superior Sagittal Sinus by MRI in Idiopathic Intracranial Hypertension: A Preliminary Study,” Neuroradiology, 36, pp. 350–354.
Alperin,  N., Vikingstad,  E. M., Gomez-Anson,  B., and Levin,  D. N., 1996, “Hemodynamically Independent Analysis of Cerebrospinal Fluid and Brain Motion Observed With Dynamic Phase Contrast MRI,” Magn. Reson. Med., 35, 741–754.
Greitz,  D., Wirestam,  R., Franck,  A., Nordell,  B., Thomsen,  C., and Ståhlberg,  F., 1992, “Pulsatile Brain Movement and Associated Hydrodynamics Studied by Magnetic Resonance Phase Imaging. The Monro–Kellie Doctrine Revisited,” Neuroradiology, 34, pp. 370–380.
Joelsz,  F. A., Patz,  S., Hawkes,  R. C., and Wallman,  J. K., 1986, “Mapping of Normal and Abnormal Cerebrospinal Fluid Flow/Motion Patterns Using Steady State Free Precession Imaging,” Acta Radiol., Suppl., 369, pp. 302–304.
Levy,  L. M., and Di Chiro,  G., 1990, “MR Phase Imaging and Cerebrospinal Fluid Flow in the Head and Spine,” Neuroradiology, 32, pp. 399–406.
Bhadelia,  R. A., Bogdan,  A. R., Wolpert,  S. M., Lev,  S., Appingnani,  B. A., and Heilman,  C. B., 1995, “Cerebrospinal Fluid Flow Waveforms: Analysis of Cerebrospinal Fluid Flow Waveforms With Gated Phase-Contrast MR Velocity Measurements,” Radiology, 196, pp. 195–202.
Mikulis,  D. J., Wood,  M. L., Zerdoner,  O. A. M., and Poncelet,  B. P., 1994, “Oscillatory Motion of the Normal Cervical Spinal Cord,” Radiology, 192, pp. 117–121.
MacDonald,  D. A., 1982, “Fully Developed Incompressible Flow Between Non-coaxial Circular Cylinders,” Z. Angew. Math. Phys., 33, pp. 737–751.
MacDonald,  D. A., 1986, “Pulsatile Flow in a Catheterised Artery,” J. Biomech., 19, No. 3, pp. 239–249.
Roos,  R., and Lykoudis,  P. S., 1971, “The Fluid Mechanics of the Ureter With an Inserted Catheter,” J. Fluid Mech., 46, pp. 625–630.
Oldfield,  E. H., Muraszko,  K., Shawker,  T. H., and Patronas,  N. J., 1994, “Pathopysiology of Syringomyelia Associated With Chiari 1 Malformation of the Cerebellar Tonsils,” J. Neurosurg., 80, pp. 3–15.
National Library of Medicine, The Visible Human Project, 1997, http://www.nlm.nih.gov/research/visible/visible_human.html.
Hoffmann, K. A., 1989, Computational Fluid Dynamics for Engineers, Engineering Education System, Austin, TX.
Moore, K., 1980, Clinically Oriented Anatomy, 2nd ed., Williams & Wilkins, Baltimore.
Bloomfield,  I. G., Johnston,  I. H., and Bilston,  L. E., 1998, “Effects of Proteins, Blood Cells and Glucose on the Viscosity of Cerebrospinal Fluid,” Pediatr. Neurosurg., 28, pp. 246–251.
Rigler,  M., and Drasner,  K., 1991, “Distribution of Catheter Injected Local Anesthetic in a Model of Subarachroid Space,” Anesthesiology, 75, pp. 684–692.
Myers,  M. R., 1996, “A Numerical Investigation Into Factors Affecting Anesthetic Distribution During Spinal Anesthesia,” ASME J. Biomech. Eng., 29, pp. 139–149.

Figures

Grahic Jump Location
Spinal canal geometry viewed from the front and side where thin and thick lines represent the spinal cavity and cord dimensions, respectively. Scale indicates distance from the base of the skull in centimeters.
Grahic Jump Location
Cross-sectional geometry of the spinal cavity. Note: position indicated is measured from the base of the skull in centimeters.
Grahic Jump Location
Distribution of hydraulic diameter and cross-sectional area along the spinal canal
Grahic Jump Location
CSF flow waveform obtained through phase contrast MR on a healthy human subject
Grahic Jump Location
Distribution of peak Reynolds number (based on spatially average velocity) and hydraulic diameter along the spinal canal
Grahic Jump Location
Pressure gradient time trace for the circular annulus (outer radius=10 mm)
Grahic Jump Location
Wall shear stress acting on the spinal cord during the cardiac cycle for circular annulus
Grahic Jump Location
Velocity profiles for the circular annulus at different times during the cycle (external and internal radius are 10 and 3 mm, respectively, α=16)
Grahic Jump Location
Velocity profiles for the circular annulus at different times during the cycle (external and internal radius are 10 and 9 mm, respectively, α=2.3)
Grahic Jump Location
Computational grids for elliptic spinal cavity and circular spinal cord with and without eccentricity: LEFT = concentric, RIGHT = eccentric
Grahic Jump Location
Velocity distributions for an elliptic outer wall and concentric circular spinal cord at four time points during the cardiac cycle (α=7.6): A=peak flow at systole, B=deceleration end systole, C=near zero flow after systole, D=reverse flow during diastole
Grahic Jump Location
The peak velocity distribution for eccentric circular/elliptic spinal boundaries (α=7.6)
Grahic Jump Location
Peak pressure gradient (Pa/mm) multiplied by flow area (mm2) as a function of flow area for the circular annulus
Grahic Jump Location
Phase-contrast MRI images of the CSF pulsatile flow during systole [LEFT] and diastole [RIGHT] along with the corresponding velocity profile. The velocity profile is anterior-to-posterior at the location indicated by a white dotted line. Note that the CSF image has been rotated by 90 deg from the previous orientation in Figs. 2 and 10.

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In