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SPECIAL PAPERS ON MICROSYSTEMS TECHNOLOGY IN MEDICINE AND BIOLOGY

Electrical, Chemical, and Topological Addressing of Mammalian Cells With Microfabricated Systems

[+] Author and Article Information
R. Kapur

Center for Bioresource Development, George Mason University, Fairfax, VA, 22030; Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348

J. M. Calvert, A. S. Rudolph

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348

J Biomech Eng 121(1), 65-72 (Feb 01, 1999) (8 pages) doi:10.1115/1.2798044 History: Received June 06, 1998; Revised October 01, 1998; Online October 30, 2007

Abstract

This communication describes our work in electrical, topological, and chemical micromodification of surfaces to modulate cellular form and function. We have addressed the surface physico-chemico-mechano properties of cell culture substrates that play a role in modulating cellular behavior. Single factorial model systems have been built using techniques adapted from microlithography. The tools and techniques of microfabrication, if harnessed and used correctly, can be enabling in elucidating the underlying principles and fundamental forces driving the cell–substrate interface. Additionally, the long-term practical applications of microfabrication in medicine and biomaterial/tissue engineering lie in enabling “communication” with living cells/tissues at the cellular and subcellular levels.

Copyright © 1999 by The American Society of Mechanical Engineers
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