Theoretical and Experimental Study of Intermittent Blood Flows in Microcirculation: Application to the in-Vivo Determination of Compliance

[+] Author and Article Information
G. Guiffant, L. Gabet, J. Dufaux

Laboratoire de Biorhéologie et d’Hydrodynamique Physico-chimique, Université Paris 7 Denis Diderot, CNRS URA 343, 2 pl. Jussieu, Paris 75005, France

J Biomech Eng 120(6), 737-742 (Dec 01, 1998) (6 pages) doi:10.1115/1.2834887 History: Received January 21, 1996; Revised July 08, 1998; Online January 23, 2008


A new theoretical approach was used to study the nonlinear response of a microvascular segment subjected to a pressure step at one end. The method is suitable for both large and small deformations of the vessel wall in the case of an elastic response of the segment. It is shown that the use of this simulation permits an indirect determination of the compliance of the vessel. The procedure is applied in two cases of major interest: first the in-vivo study of the intermittent blood flow in the microcirculation, and second, the analysis of experiments using micropipettes. The resulting values of the compliance agree with other values found in the previous studies. The theoretical method is particularly adapted to nonlinear equations.

Copyright © 1998 by The American Society of Mechanical Engineers
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