Pulsatile Flow Computational Simulations of Mitral Regurgitation

[+] Author and Article Information
J. Hopmeyer, P. W. Wilkerson, K. M. Thorvig, A. P. Yoganathan

Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, and the Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0100

R. A. Levine

Non-Invasive Cardiology Laboratory, Massachusetts General Hospital, Department of Medicine, Cambridge, MA 02000

J Biomech Eng 120(2), 245-254 (Apr 01, 1998) (10 pages) doi:10.1115/1.2798308 History: Received August 22, 1996; Revised April 03, 1997; Online October 30, 2007


The noninvasive quantification of mitral regurgitation remains an important clinical goal. Recently, the flow convergence method was developed to estimate the regurgitant flow rate. This study used three-dimensional pulsatile flow computational simulations to evaluate the accuracy of the flow convergence method in the presence of complicating factors such as ventricular confinement, noncircular orifice shape, and the presence of aortic outflow. Results showed that in the absence of aortic outflow and ventricular confinement, there was a plateau zone where the calculated flow rate by the hemispheric formula approximated the true flow rate, independent of the orifice shape. In the presence of aortic outflow and in chambers of physiologic dimensions, there was no longer a clear zone where the hemispheric formula was valid. The hemi-elliptic modiflcation of the flow convergence method worked in all cases, independent of the degree of ventricular confinement or the presence of aortic outflow. Therefore, application of the hemi-elliptic formula should be considered in future clinical studies.

Copyright © 1998 by The American Society of Mechanical Engineers
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