A 3D-LDA Study of the Relation Between Wall Shear Stress and Intimal Thickness in a Human Aortic Bifurcation

[+] Author and Article Information
Kozaburo Hayashi

Department of Mechanical Engineering, Osaka University, Toyonaka, Osaka 560, Japan

Yutaka Yanai, Takeru Naiki

Section of Scientific Instrumentation and Control, Research Institute for Electronic Science, Hokkaido University, Sapporo 060, Japan

J Biomech Eng 118(3), 273-279 (Aug 01, 1996) (7 pages) doi:10.1115/1.2796007 History: Received October 19, 1994; Revised July 11, 1995; Online October 30, 2007


A realistic model experiment on hemodynamics was performed to study correlations between wall shear stresses measured in a cast model of the aortic bifurcation and intimal thickness at each corresponding site of the native blood vessel from which the cast had been made. An elastic model of a 54 year old human aortic bifurcation was made of a polyurethane elastomer using a dipping method, and was perfused with Newtonian or non-Newtonian fluid under physiologic pulsatile flow condition. Local flow velocities were measured with an optical-fibered, 3-dimensional laser Doppler anemometer (3D-LDA) to determine wall shear stresses. Distribution of intimal thickness was determined using histological specimens of the native blood vessel. The results obtained are: 1) Non-Newtonian fluid rheology increased wall shear stresses; 2) Positive correlations were observed between intimal thickness and the maximum instantaneous wall shear stress, and 3) However, if we take only the data from the circumference at the level of the flow divider tip, there were negative correlations between them.

Copyright © 1996 by The American Society of Mechanical Engineers
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