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TECHNICAL PAPERS

Biomechanical Model for the Myogenic Response in the Microcirculation: Part I—Formulation and Initial Testing

[+] Author and Article Information
Shouyan Lee, Geert W. Schmid-Schönbein

Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0412

J Biomech Eng 118(2), 145-151 (May 01, 1996) (7 pages) doi:10.1115/1.2795952 History: Received August 28, 1993; Revised February 27, 1995; Online October 30, 2007

Abstract

The pressure dependent or myogenic contraction of arterioles is one of the most fundamental control mechanisms of microvascular perfusion. While many experimental observations have been obtained on the myogenic response, no generally accepted biomechanical model has been formulated. A novel biomechanical theory is proposed based on two fundamental assumptions: the arteriolar wall exhibits viscoelastic properties before and during myogenic contractions, and the contraction is achieved by a pressure dependent change of reference length. The formulation of the model and its application to different experimental procedures on microvascular smooth muscle in the literature is presented. The model describes closely a broad spectrum of steady and unsteady pressure dependent diameter variations of arterioles under a pressure dependent stimulus.

Copyright © 1996 by The American Society of Mechanical Engineers
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