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TECHNICAL PAPERS

Hindered Transport of Macromolecules Through a Single Row of Cylinders: Application to Glomerular Filtration

[+] Author and Article Information
M. C. Drumond, W. M. Deen

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

J Biomech Eng 117(4), 414-422 (Nov 01, 1995) (9 pages) doi:10.1115/1.2794202 History: Revised November 15, 1993; Received October 19, 1994; Online October 30, 2007

Abstract

The slit diaphragms of renal glomerular capillaries form an ultrafiltration barrier which may be approximated as a row of cylindrical fibers of macromolecular dimensions. To describe the hindered transport of plasma proteins and other macromolecules through this barrier, we developed an approximate hydrodynamic model for spherical, Brownian particles passing through a row of infinitely long cylinders. The selectivity of the slit diaphragm was assessed by computing concentration profiles for a wide range of molecular sizes for Pe ≤ 1, where Pe is a Peclet number based on the cylinder radius. The sieving coefficient for the slit diaphragm was computed as θSD = CB /CO , where CO was the average concentration at a specified distance upstream from the cylinders (corresponding to the location of the basement membrane), and CB was the concentration far downstream (corresponding to Bowman’s space). The results of previous experimental sieving studies using rats could be accounted for approximately by postulating a wide distribution of spacings between the fibers of the slit diaphragm. Comparing the results for θSD with calculations for a model of the glomerular basement membrane suggests that the slit diaphragm is by far the more size-restrictive part of the overall barrier.

Copyright © 1995 by The American Society of Mechanical Engineers
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